SHC1

SHC (Src homology 2 domain containing) transforming protein 1
PDB rendering based on 1mil.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1MIL, 1N3H, 1OY2, 1QG1, 1SHC, 1TCE, 2L1C
Identifiers
Symbols	SHC1; SHC; SHCA
External IDs	OMIM: 600560 MGI: 98296 HomoloGene: 7934 ChEMBL: 5626 GeneCards: SHC1 Gene
Gene Ontology Molecular function • protein tyrosine kinase activity • transmembrane receptor protein tyrosine kinase adaptor activity • epidermal growth factor receptor binding • insulin receptor binding • insulin-like growth factor receptor binding • neurotrophin TRKA receptor binding • protein binding • phospholipid binding • ephrin receptor binding Cellular component • mitochondrial matrix • cytosol • plasma membrane • Shc-EGFR complex Biological process • MAPK cascade • activation of MAPK activity • angiogenesis • activation of signaling protein activity involved in unfolded protein response • epidermal growth factor receptor signaling pathway • regulation of epidermal growth factor-activated receptor activity • Ras protein signal transduction • heart development • blood coagulation • positive regulation of cell proliferation • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • cell-cell adhesion • platelet activation • endoplasmic reticulum unfolded protein response • actin cytoskeleton reorganization • regulation of growth • cellular protein metabolic process • innate immune response • positive regulation of DNA replication • neurotrophin TRK receptor signaling pathway • leukocyte migration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6464	20416
Ensembl	ENSG00000160691	ENSMUSG00000042626
UniProt	P29353	P98083
RefSeq (mRNA)	NM_001130040	NM_001113331
RefSeq (protein)	NP_001123512	NP_001106802
Location (UCSC)	Chr 1: 154.93 – 154.95 Mb	Chr 3: 89.42 – 89.43 Mb
PubMed search
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SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene.^[1] SHC has been found to be important in the regulation of apoptosis and drug resistance in mammalian cells.

SCOP classifies the 3D structure as belonging to the SH2 domain family.

References

Further reading

v t e PDB gallery 1mil: TRANSFORMING PROTEIN  1n3h: Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc  1oy2: Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc  1shc: SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE  1tce: SOLUTION NMR STRUCTURE OF THE SHC SH2 DOMAIN COMPLEXED WITH A TYROSINE-PHOSPHORYLATED PEPTIDE FROM THE T-CELL RECEPTOR, MINIMIZED AVERAGE STRUCTURE