SEC23A
From Wikipedia, the free encyclopedia
Sec23 homolog A (S. cerevisiae), also known as SEC23A, is a protein which in humans is encoded by the SEC23A gene.[1]
Function
The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking.[1]
SEC23 interacts with both SEC16A and SEC16B.[citation needed]
Interactions
SEC23A has been shown to interact with SEC24C,[2] Sec16A/p250 and iPLA1β/p125.[3]
Sec23 has been shown to interact with TRAPPⅠ, Grh1p also known as GRASP65 and Dynactin. Because they are involved in anterograde vesicle transport from ER to Golgi, Sec23 is involved in vesicle transport.[4]
References
- ↑ 1.0 1.1 "Entrez Gene: SEC23A Sec23 homolog A (S. cerevisiae)".
- ↑ Pagano, A; Letourneur F, Garcia-Estefania D, Carpentier J L, Orci L, Paccaud J P (Mar 1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J. Biol. Chem. (UNITED STATES) 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. ISSN 0021-9258. PMID 10075675.
- ↑ p125 is localized in endoplasmic reticulum exit sites and involved in their organization.
- ↑ Coordination of COPII vesicle trafficking by Sec23.
Further reading
- Paccaud JP, Reith W, Carpentier JL et al. (1997). "Cloning and functional characterization of mammalian homologues of the COPII component Sec23". Mol. Biol. Cell 7 (10): 1535–46. PMC 276004. PMID 8898360.
- Pagano A, Letourneur F, Garcia-Estefania D et al. (1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J. Biol. Chem. 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID 10075675.
- Tang BL, Kausalya J, Low DY et al. (1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem. Biophys. Res. Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Heilig R, Eckenberg R, Petit JL et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
- Boyadjiev SA, Justice CM, Eyaid W et al. (2003). "A novel dysmorphic syndrome with open calvarial sutures and sutural cataracts maps to chromosome 14q13-q21". Hum. Genet. 113 (1): 1–9. doi:10.1007/s00439-003-0932-6. PMID 12677423.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Dudognon P, Maeder-Garavaglia C, Carpentier JL, Paccaud JP (2004). "Regulation of a COPII component by cytosolic O-glycosylation during mitosis". FEBS Lett. 561 (1–3): 44–50. doi:10.1016/S0014-5793(04)00109-7. PMID 15013749.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Watson P, Forster R, Palmer KJ et al. (2005). "Coupling of ER exit to microtubules through direct interaction of COPII with dynactin". Nat. Cell Biol. 7 (1): 48–55. doi:10.1038/ncb1206. PMC 1592520. PMID 15580264.
- Palmer KJ, Konkel JE, Stephens DJ (2005). "PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport". J. Cell. Sci. 118 (Pt 17): 3839–47. doi:10.1242/jcs.02496. PMID 16091426.
- Boyadjiev SA, Fromme JC, Ben J et al. (2006). "Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking". Nat. Genet. 38 (10): 1192–7. doi:10.1038/ng1876. PMID 16980979.
- Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells". Mol. Cell Proteomics 6 (4): 575–88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478.
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