SCN10A

From Wikipedia, the free encyclopedia

Sodium channel, voltage-gated, type X, alpha subunit

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1byy

Identifiers

Symbols

SCN10A; Nav1.8; PN3; SNS; hPN3

External IDs

OMIM: 604427 MGI: 108029 HomoloGene: 21300 IUPHAR: Na_v1.8 ChEMBL: 5451 GeneCards: SCN10A Gene

Gene Ontology
Molecular function	• voltage-gated sodium channel activity
Cellular component	• voltage-gated sodium channel complex • C-fiber
Biological process	• regulation of heart rate • sodium ion transport • sensory perception • regulation of ion transmembrane transport • sodium ion transmembrane transport • regulation of cardiac muscle contraction • regulation of atrial cardiac muscle cell membrane depolarization • AV node cell to bundle of His cell communication • bundle of His cell to Purkinje myocyte communication
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
38.74 – 38.84 Mb

Chr 9:
119.61 – 119.72 Mb

PubMed search

Sodium channel, voltage gated, type X, alpha subunit also known as SCN10A or Na_v1.8 is a protein which in humans is encoded by the SCN10A gene.^[1]

Na_v1.8 is a sodium channel subunit.^[2]^[3]^[4]

Function

This subtype of voltage-gated sodium channel is expressed in nociceptors and has been proposed as a target for the development of new analgesics.^[5]

In 2013, Bezzina & al showed that common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome.^[6]

References

↑ "Entrez Gene: sodium channel".
↑ Rabert DK, Koch BD, Ilnicka M, Obernolte RA, Naylor SL, Herman RC, Eglen RM, Hunter JC, Sangameswaran L (November 1998). "A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A". Pain 78 (2): 107–14. doi:10.1016/S0304-3959(98)00120-1. PMID 9839820.
↑ Plummer NW, Meisler MH (April 1999). "Evolution and diversity of mammalian sodium channel genes". Genomics 57 (2): 323–31. doi:10.1006/geno.1998.5735. PMID 10198179.
↑ Catterall WA, Goldin AL, Waxman SG (December 2005). "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels". Pharmacol. Rev. 57 (4): 397–409. doi:10.1124/pr.57.4.4. PMID 16382098.
↑ Cummins TR, Sheets PL, Waxman SG (October 2007). "Voltage-gated sodium channel blockers for the treatment of chronic pain". Pain 131 (3): 243–57. PMID 19442207.
↑ Bezzina, Connie R; Barc, Julien; Mizusawa, Yuka; Remme, Carol Ann; Gourraud, Jean-Baptiste; Simonet, Floriane; Verkerk, Arie O; Schwartz, Peter J; Crotti, Lia; Dagradi, Federica; Guicheney, Pascale; Fressart, Véronique; Leenhardt, Antoine; Antzelevitch, Charles; Bartkowiak, Susan; Schulze-Bahr, Eric; Zumhagen, Sven; Behr, Elijah R; Bastiaenen, Rachel; Tfelt-Hansen, Jacob; Olesen, Morten Salling; Kääb, Stefan; Beckmann, Britt M; Weeke, Peter; Watanabe, Hiroshi; Endo, Naoto; Minamino, Tohru; Horie, Minoru; Ohno, Seiko; Hasegawa, Kanae; Makita, Naomasa; Nogami, Akihiko; Shimizu, Wataru; Aiba, Takeshi; Froguel, Philippe; Balkau, Beverley; Lantieri, Olivier; Torchio, Margherita; Wiese, Cornelia; Weber, David; Wolswinkel, Rianne; Coronel, Ruben; Boukens, Bas J; Bézieau, Stéphane; Charpentier, Eric; Chatel, Stéphanie; Despres, Aurore; Gros, Françoise; Kyndt, Florence; Lecointe, Simon; Lindenbaum, Pierre; Portero, Vincent; Violleau, Jade; Gessler, Manfred; Tan, Hanno L; Roden, Dan M; Christoffels, Vincent M; Marec, Hervé Le; Wilde, Arthur A; Probst, Vincent; Schott, Jean-Jacques; Dina, Christian; Redon, Richard (2013). "Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death". Nature Genetics. doi:10.1038/ng.2712. ISSN 1061-4036.

Malik-Hall M, Poon WY, Baker MD, et al. (2003). "Sensory neuron proteins interact with the intracellular domains of sodium channel NaV1.8.". Brain Res. Mol. Brain Res. 110 (2): 298–304. doi:10.1016/S0169-328X(02)00661-7. PMID 12591166.
Yamaoka K, Inoue M, Miyazaki K, et al. (2009). "Synthetic Ciguatoxins Selectively Activate Nav1.8-derived Chimeric Sodium Channels Expressed in HEK293 Cells". J. Biol. Chem. 284 (12): 7597–605. doi:10.1074/jbc.M806481200. PMC 2658054. PMID 19164297.
Choi JS, Hudmon A, Waxman SG, Dib-Hajj SD (2006). "Calmodulin regulates current density and frequency-dependent inhibition of sodium channel Nav1.8 in DRG neurons". J. Neurophysiol. 96 (1): 97–108. doi:10.1152/jn.00854.2005. PMID 16598065.
Liu CJ, Priest BT, Bugianesi RM, et al. (2006). "A high-capacity membrane potential FRET-based assay for NaV1.8 channels". Assay and drug development technologies 4 (1): 37–48. doi:10.1089/adt.2006.4.37. PMID 16506887.
Browne LE, Blaney FE, Yusaf SP, et al. (2009). "Structural Determinants of Drugs Acting on the Nav1.8 Channel". J. Biol. Chem. 284 (16): 10523–36. doi:10.1074/jbc.M807569200. PMC 2667739. PMID 19233853.
Rabert DK, Koch BD, Ilnicka M, et al. (1998). "A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A". Pain 78 (2): 107–14. doi:10.1016/S0304-3959(98)00120-1. PMID 9839820.
Plummer NW, Meisler MH (1999). "Evolution and diversity of mammalian sodium channel genes". Genomics 57 (2): 323–31. doi:10.1006/geno.1998.5735. PMID 10198179.
Catterall WA, Goldin AL, Waxman SG (2005). "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels". Pharmacol. Rev. 57 (4): 397–409. doi:10.1124/pr.57.4.4. PMID 16382098.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3

Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ

Proton-gated	Amiloride-sensitive cation channel 1 2 3 4

Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1

Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1

Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18

Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker gene

Miscellaneous

Cl^-: Chloride channel	ANO1 Bestrophin 1 2 CFTR CLCA 1 2 3 4 CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B

H⁺: Proton channel	HVCN1

M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4

M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6

H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family

Cytoplasm: Gap junction	Connexin: A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4) Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), other

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SCN10A

Function

References

Further reading