SCH 23390
From Wikipedia, the free encyclopedia
| SCH 23390 | ||
|---|---|---|
 | ||
| IUPAC name 7-chloro-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-ol | ||
| Identifiers | ||
| CAS number | 87075-17-0  | |
| PubChem | 5018 | |
| ChEBI | CHEBI:73297  | |
| ChEMBL | CHEMBL62 | |
| IUPHAR ligand | 943 | |
| Jmol-3D images | Image 1 | |
| ||
| Properties | ||
| Molecular formula | C17H18ClNO | |
| Molar mass | 287.78 g/mol | |
| (verify) (what is: /?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | ||
| Infobox references | ||
SCH 23390 is a synthetic compound that acts as a D1 receptor antagonist and has either minimal or negligible effects on the D2 receptor.
In a 1990 study in rats SCH 23390 offered significant protection from death in dextroamphetamine overdosage, without providing protection from death by methamphetamine overdose. The compound provided significant protection from cocaine overdose in rats only at the lowest dose tested in the measurement series. This suggested that d-amphetamine and methamphetamine at high (lethal) doses have different mechanisms of toxicity in rats.[1]
References
- ↑ Derlet, R. W.; Albertson, T. E.; Rice, P. (1990). "The Effect of SCH 23390 Against Toxic Doses of Cocaine, d-Amphetamine and Methamphetamine". Life Sciences 47 (9): 821–827. doi:10.1016/0024-3205(90)90555-6. PMID 2215083.
This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.