Rufinamide
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|---|---|
| Systematic (IUPAC) name | |
| 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide | |
| Clinical data | |
| AHFS/Drugs.com | Consumer Drug Information |
| MedlinePlus | a609001 |
| Licence data | EMA:Link, US FDA:link |
| Legal status | ℞ Prescription only |
| Routes | Oral |
| Identifiers | |
| CAS number | 106308-44-5  |
| ATC code | N03AF03 |
| PubChem | CID 129228 |
| ChemSpider | 114471  |
| UNII | WFW942PR79 |
| ChEMBL | CHEMBL1201754 |
| Chemical data | |
| Formula | C10H8F2N4O |
| Mol. mass | 238.194 |
| SMILES
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| (what is this?) (verify) | |
Rufinamide is an anticonvulsant medication. It is used in combination with other medication and therapy to treat Lennox–Gastaut syndrome[1] and various other seizure disorders. Rufinamide, a triazole derivative, was developed in 2004 by Novartis Pharma, AG, and is manufactured by Eisai.
Rufinamide was approved by the US Food and Drug Administration on November 14, 2008 as adjunctive treatment of seizures associated with Lennox-Gastaut syndrome in children 4 years and older and adults. Its official FDA-approved labeling does not mention use in the treatment of partial seizures inasmuch as clinical trials submitted to the FDA were marginal. However, several recent clinical trials suggest that the drug has efficacy for partial seizures [2] It is marketed under the brand name Banzel.[3] It is also marketed in the European Union under the brand name Inovelon.[4]
The mechanism of action of rufinamide is unknown. However, it is presumed to involve stabilization of the sodium channel inactive state, effectively keeping these ion channels closed. Although the direct mechanism of action may be different, several other antiepileptic agents also stabilize a sodium channel inactive state including phenytoin, carbamazepine, and lacosamide (stabilizes the slow inactive state).
References
- ↑ Hakimian S, Cheng-Hakimian A, Anderson GD, Miller JW (August 2007). "Rufinamide: a new anti-epileptic medication". Expert Opin Pharmacother 8 (12): 1931–40. doi:10.1517/14656566.8.12.1931. PMID 17696794.
- ↑ Brodie MJ, Rosenfeld WE, Vazquez B, Sachdeo R, Perdomo C, Mann A, Arroyo S (August 2009). "Rufinamide for the adjunctive treatment of partial seizures in adults and adolescents: a randomized placebo-controlled trial". Epilepsia 50 (8): 1899–909. doi:10.1111/j.1528-1167.2009.02160.x. PMID 19490053.
- ↑ FDA press release - FDA Approves New Drug to Treat Severe Form of Epilepsy
- ↑ European Public Assessment Report for rufinamide (INOVELON)
External links
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