Rogletimide

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Rogletimide
Systematic (IUPAC) name
3-ethyl-3-(pyridin-4-yl)piperidine-2,6-dione
Clinical data
Legal status ?
Identifiers
CAS number 121840-95-7
ATC code ?
PubChem CID 56487
ChemSpider 50963
UNII 14P4QR28QF YesY
Chemical data
Formula C12H14N2O2 
Mol. mass 218.25 g/mol

Rogletimide is a drug related in chemical structure to the sedative glutethimide, but instead having pharmacological activity as a selective aromatase inhibitor similar to the related drug aminoglutethimide, but with no significant sedative effect.[1] This makes it potentially useful in the treatment of some forms of cancer, and with less side effects than aminoglutethimide, but its lower potency caused it to be unsuccessful in clinical trials.[2]

References

  1. ↑ Vanden Bossche HV, Moereels H, Koymans LM (1994). "Aromatase inhibitors--mechanisms for non-steroidal inhibitors". Breast Cancer Research and Treatment 30 (1): 43–55. PMID 7949204. 
  2. ↑ MacNeill FA, Jones AL, Jacobs S, Lønning PE, Powles TJ, Dowsett M (October 1992). "The influence of aminoglutethimide and its analogue rogletimide on peripheral aromatisation in breast cancer". British Journal of Cancer 66 (4): 692–7. doi:10.1038/bjc.1992.339. PMC 1977412. PMID 1419608. 

See also

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