Rnd2
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| Rho family GTPase 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | RND2; ARHN; RHO7; RhoN | ||||||||||||
| External IDs | OMIM: 601555 MGI: 1338755 HomoloGene: 21123 GeneCards: RND2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8153 | 11858 | |||||||||||
| Ensembl | ENSG00000108830 | ENSMUSG00000001313 | |||||||||||
| UniProt | P52198 | Q9QYM5 | |||||||||||
| RefSeq (mRNA) | NM_005440 | NM_009708 | |||||||||||
| RefSeq (protein) | NP_005431 | NP_033838 | |||||||||||
| Location (UCSC) | Chr 17: 41.18 – 41.18 Mb | Chr 11: 101.46 – 101.47 Mb | |||||||||||
| PubMed search | |||||||||||||
Rnd2 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.[1] It is encoded by the gene RND2.[2]
It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM][2]
This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking.
The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1.[2]
Interactions
Rnd2 has been shown to interact with RACGAP1,[3] ARHGAP5[4] and UBXD5.[5]
References
- ↑ Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. ISSN 0962-8924. PMID 16949823.
- ↑ 2.0 2.1 2.2 "Entrez Gene: RND2 Rho family GTPase 2".
- ↑ Naud, Nathalie; Touré Aminata, Liu Jianfeng, Pineau Charles, Morin Laurence, Dorseuil Olivier, Escalier Denise, Chardin Pierre, Gacon Gérard (May 2003). "Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells". Biochem. J. (England) 372 (Pt 1): 105–12. doi:10.1042/BJ20021652. ISSN 0264-6021. PMC 1223378. PMID 12590651.
- ↑ Wennerberg, Krister; Forget Marie-Annick, Ellerbroek Shawn M, Arthur William T, Burridge Keith, Settleman Jeffrey, Der Channing J, Hansen Steen H (Jul 2003). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Curr. Biol. (England) 13 (13): 1106–15. doi:10.1016/S0960-9822(03)00418-4. ISSN 0960-9822. PMID 12842009.
- ↑ Katoh, Hironori; Harada Amane, Mori Kazutoshi, Negishi Manabu (May 2002). "Socius Is a Novel Rnd GTPase-Interacting Protein Involved in Disassembly of Actin Stress Fibers". Mol. Cell. Biol. (United States) 22 (9): 2952–64. doi:10.1128/MCB.22.9.2952-2964.2002. ISSN 0270-7306. PMC 133765. PMID 11940653.
Further reading
- Chardin P (1991). "Small GTP-binding proteins of the ras family: a conserved functional mechanism?". Cancer Cells 3 (4): 117–26. PMID 1909153.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Smith TM, Lee MK, Szabo CI et al. (1997). "Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1". Genome Res. 6 (11): 1029–49. doi:10.1101/gr.6.11.1029. PMID 8938427.
- Nobes CD, Lauritzen I, Mattei MG et al. (1998). "A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion". J. Cell Biol. 141 (1): 187–97. doi:10.1083/jcb.141.1.187. PMC 2132722. PMID 9531558.
- Tanaka H, Fujita H, Katoh H et al. (2002). "Vps4-A (vacuolar protein sorting 4-A) is a binding partner for a novel Rho family GTPase, Rnd2". Biochem. J. 365 (Pt 2): 349–53. doi:10.1042/BJ20020062. PMC 1222680. PMID 11931639.
- Katoh H, Harada A, Mori K, Negishi M (2002). "Socius Is a Novel Rnd GTPase-Interacting Protein Involved in Disassembly of Actin Stress Fibers". Mol. Cell. Biol. 22 (9): 2952–64. doi:10.1128/MCB.22.9.2952-2964.2002. PMC 133765. PMID 11940653.
- Fujita H, Katoh H, Ishikawa Y et al. (2003). "Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching". J. Biol. Chem. 277 (47): 45428–34. doi:10.1074/jbc.M208090200. PMID 12244061.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Naud N, Touré A, Liu J et al. (2003). "Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells". Biochem. J. 372 (Pt 1): 105–12. doi:10.1042/BJ20021652. PMC 1223378. PMID 12590651.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Kim YS, Hori M, Yasuda K, Ozaki H (2006). "Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria". Comp. Biochem. Physiol., Part a Mol. Integr. Physiol. 142 (4): 410–5. doi:10.1016/j.cbpa.2005.08.028. PMID 16311049.
- Tanaka H, Katoh H, Negishi M (2006). "Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity". J. Biol. Chem. 281 (15): 10355–64. doi:10.1074/jbc.M511314200. PMID 16481321.
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