Rnd1
From Wikipedia, the free encyclopedia
| Rho family GTPase 1 | |||||||||||||
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 PDB rendering based on 2cls. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | RND1; ARHS; RHO6; RHOS | ||||||||||||
| External IDs | OMIM: 609038 MGI: 2444878 HomoloGene: 8706 GeneCards: RND1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 27289 | 223881 | |||||||||||
| Ensembl | ENSG00000172602 | ENSMUSG00000054855 | |||||||||||
| UniProt | Q92730 | Q8BLR7 | |||||||||||
| RefSeq (mRNA) | NM_014470 | NM_172612 | |||||||||||
| RefSeq (protein) | NP_055285 | NP_766200 | |||||||||||
| Location (UCSC) | Chr 12: 49.25 – 49.26 Mb | Chr 15: 98.66 – 98.68 Mb | |||||||||||
| PubMed search | |||||||||||||
Rnd1 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.[1] It is encoded by the gene RND1.[2]
It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM][2]
Interactions
Rnd1 has been shown to interact with GRB7,[3] PLXNB1,[4] PDE6D,[5][6] ARHGAP5[7] and UBXD5.[8]
References
- ↑ Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. ISSN 0962-8924. PMID 16949823.
- ↑ 2.0 2.1 "Entrez Gene: RND1 Rho family GTPase 1".
- ↑ Vayssière, B; Zalcman G, Mahé Y, Mirey G, Ligensa T, Weidner K M, Chardin P, Camonis J (February 2000). "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family". FEBS Lett. (NETHERLANDS) 467 (1): 91–6. doi:10.1016/S0014-5793(99)01530-6. ISSN 0014-5793. PMID 10664463.
- ↑ Oinuma, Izumi; Katoh Hironori, Harada Amane, Negishi Manabu (July 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. (United States) 278 (28): 25671–7. doi:10.1074/jbc.M303047200. ISSN 0021-9258. PMID 12730235.
- ↑ Nancy, Vanessa; Callebaut Isabelle, El Marjou Ahmed, de Gunzburg Jean (April 2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". J. Biol. Chem. (United States) 277 (17): 15076–84. doi:10.1074/jbc.M109983200. ISSN 0021-9258. PMID 11786539.
- ↑ Hanzal-Bayer, Michael; Renault Louis, Roversi Pietro, Wittinghofer Alfred, Hillig Roman C (May 2002). "The complex of Arl2-GTP and PDEδ: from structure to function". EMBO J. (England) 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. ISSN 0261-4189. PMC 125981. PMID 11980706.
- ↑ Wennerberg, Krister; Forget Marie-Annick, Ellerbroek Shawn M, Arthur William T, Keith Burridge, Settleman Jeffrey, Der Channing J, Hansen Steen H (July 2003). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Curr. Biol. (England) 13 (13): 1106–15. doi:10.1016/S0960-9822(03)00418-4. ISSN 0960-9822. PMID 12842009.
- ↑ Katoh, Hironori; Harada Amane, Mori Kazutoshi, Negishi Manabu (May 2002). "Socius Is a Novel Rnd GTPase-Interacting Protein Involved in Disassembly of Actin Stress Fibers". Mol. Cell. Biol. (United States) 22 (9): 2952–64. doi:10.1128/MCB.22.9.2952-2964.2002. ISSN 0270-7306. PMC 133765. PMID 11940653.
Further reading
- Nobes CD, Lauritzen I, Mattei MG et al. (1998). "A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion". J. Cell Biol. 141 (1): 187–97. doi:10.1083/jcb.141.1.187. PMC 2132722. PMID 9531558.
- Vayssière B, Zalcman G, Mahé Y et al. (2000). "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family". FEBS Lett. 467 (1): 91–6. doi:10.1016/S0014-5793(99)01530-6. PMID 10664463.
- Aoki J, Katoh H, Mori K, Negishi M (2001). "Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells". Biochem. Biophys. Res. Commun. 278 (3): 604–8. doi:10.1006/bbrc.2000.3842. PMID 11095956.
- Rohm B, Rahim B, Kleiber B et al. (2001). "The semaphorin 3A receptor may directly regulate the activity of small GTPases". FEBS Lett. 486 (1): 68–72. doi:10.1016/S0014-5793(00)02240-7. PMID 11108845.
- Nancy V, Callebaut I, El Marjou A, de Gunzburg J (2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". J. Biol. Chem. 277 (17): 15076–84. doi:10.1074/jbc.M109983200. PMID 11786539.
- Katoh H, Harada A, Mori K, Negishi M (2002). "Socius Is a Novel Rnd GTPase-Interacting Protein Involved in Disassembly of Actin Stress Fibers". Mol. Cell. Biol. 22 (9): 2952–64. doi:10.1128/MCB.22.9.2952-2964.2002. PMC 133765. PMID 11940653.
- Hanzal-Bayer M, Renault L, Roversi P et al. (2002). "The complex of Arl2-GTP and PDEδ: from structure to function". EMBO J. 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMC 125981. PMID 11980706.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Oinuma I, Katoh H, Harada A, Negishi M (2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.
- Oinuma I, Ishikawa Y, Katoh H, Negishi M (2004). "The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras". Science 305 (5685): 862–5. doi:10.1126/science.1097545. PMID 15297673.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Harada A, Katoh H, Negishi M (2005). "Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells". J. Biol. Chem. 280 (18): 18418–24. doi:10.1074/jbc.M411356200. PMID 15738000.
- Kim YS, Hori M, Yasuda K, Ozaki H (2006). "Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria". Comp. Biochem. Physiol., Part a Mol. Integr. Physiol. 142 (4): 410–5. doi:10.1016/j.cbpa.2005.08.028. PMID 16311049.
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