Rifampicin/isoniazid/pyrazinamide

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Rifampicin/isoniazid/pyrazinamide
Combination of
Rifampicin Rifamycin antibiotic
Isoniazid First-line anti-tuberculosis medication
Pyrazinamide Anti-tuberculosis medication
Clinical data
Trade names Rifater, Trifazid
AHFS/Drugs.com FDA Professional Drug Information
Pregnancy cat. C
Legal status ℞ Prescription only
Routes Oral
Identifiers
ATC code J04AM05
PubChem CID 6474062
 YesY (what is this?)  (verify)

Rifampicin/isoniazid/pyrazinamide (trade name Rifater) is a fixed dose combination tablet manufactured by Aventis used in the treatment of tuberculosis. Each tablet contains 120 mg rifampicin, 50 mg isoniazid and 300 mg pyrazinamide. It is used in initial treatment of tuberculosis, typically for the first two months.[1][2]

Rifater is contraindicated in children with a body weight of under 40 kg.[2]

The purpose of the fixed dose combination is to make it easier for patients to take their medication; but also to ensure that if patients forget to take one or two of their drugs, they do not then develop resistance to the remaining drugs.

See also

  • Tuberculosis treatment

References

  1. ↑ Drugs.com: Rifater
  2. ↑ 2.0 2.1 Jasek, W, ed. (2007). Austria-Codex (in German) (2007/2008 ed.). Vienna: Österreichischer Apothekerverlag. ISBN 978-3-85200-181-4. 
Antimycobacterials, including tuberculosis treatment and leprostatic agents (J04)
Nucleic acid inhibitor
Rifamycins/
RNA polymerase inhibitor
  • Rifampicin#
  • Rifabutin
  • Rifapentine
Antifolates/DSI
  • Dapsone#
  • Acedapsone
  • Aldesulfone sodium
ASA
  • 4-Aminosalicylic acid# (Calcium aminosalicylate
  • Sodium aminosalicylate)
Protein synthesis inhibitor
Aminoglycosides
  • Amikacin#
  • Capreomycin#
  • Kanamycin#
  • Streptomycin#
Oxazolidone
  • Linezolid
Cell envelope antibiotic
Peptidoglycan layer
  • Alanine analogue: Cycloserine#
Arabinogalactan layer
  • Ethylenediamine/arabinosyltransferase inhibitor: Ethambutol#
SQ109†
Mycolic acid layer
  • Hydrazides/mycolic acid synth. inhibition: Isoniazid#
  • Thiocarbamides: Ethionamide#
  • Prothionamide
  • Thiocarlide
Other/unknown
  • Phenazine (Clofazimine)#
  • Pyrazine (Pyrazinamide#, Morinamide)
  • Isoxazole (Terizidone)
  • Bedaquiline
  • Metronidazole (delamanid)
Combinations
  • Rifampicin/isoniazid/pyrazinamide
  • #WHO-EM
  • ‡Withdrawn from market
  • Clinical trials:
    • †Phase III
    • §Never to phase III

M: BAC

bact (clas)

gr+f/gr+a (t)/gr-p (c)/gr-o

drug (J1p, w, n, m, vacc)


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