Rhynchophylline
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| Systematic (IUPAC) name | |
| methyl (7β,16E,20α)-16-(methoxymethylene)-2-oxocorynoxan- 17-oate | |
| Clinical data | |
| Legal status | ? |
| Identifiers | |
| CAS number | 76-66-4  |
| ATC code | None |
| PubChem | CID 3033948 |
| ChEMBL | CHEMBL519266  |
| Synonyms | methyl (E)-2-[(3R,6'R,7'S,8'aS)- 6'-ethyl- 2-oxospiro[1H-indole-3,1'- 3,5,6,7,8,8a-hexahydro- 2H-indolizine]- 7'-yl]- 3-methoxyprop- 2-enoate |
| Chemical data | |
| Formula | C22H28N2O4 |
| Mol. mass | 384.46872 g/mol |
| SMILES
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Rhynchophylline is an alkaloid found in certain Uncaria species (Rubiaceae), notably Uncaria rhynchophylla[1] and Uncaria tomentosa.[2] It is a non-competitive NMDA antagonist (IC50 = 43.2 microM) and calcium channel blocker.[3][4] It also occurs naturally in the leaves of the Mitragyna speciosa (Kratom) tree (also a Rubiaceae), native to Thailand.[5]
References
- ↑ Shi JS, Yu JX, Chen XP, Xu RX (2003). "Pharmacological Actions of Uncaria Alkaloids, Rhynchophylline and Isorhynchophylline" (pdf). Acta Pharmacologica Sinica 24 (2): 97–101. PMID 12546715.
- ↑ Mohamed AF, Matsumoto K, Tabata K, Takayama H, Kitajima M, Watanabe H (2000). "Effects of Uncaria tomentosa Total Alkaloid and its Components on Experimental Amnesia in Mice: Elucidation Using the Passive Avoidance Test". Journal of Pharmacy and Pharmacology 52 (12): 1553–1561. doi:10.1211/0022357001777612. PMID 11197086.
- ↑ Kang TH, Murakami Y, Matsumoto K, Takayama H, Kitajima M, Aimi N, Watanabe H (2002). "Rhynchophylline and Isorhynchophylline Inhibit NMDA Receptors Expressed in Xenopus Oocytes". European Journal of Pharmacology 455 (1): 27–34. doi:10.1016/S0014-2999(02)02581-5. PMID 12433591.
- ↑ Kang TH, Murakami Y, Takayama H, Kitajima M, Aimi N, Watanabe H, Matsumoto K (2004). "Protective Effect of Rhynchophylline and Isorhynchophylline on in vitro Ischemia-Induced Neuronal Damage in the Hippocampus: Putative Neurotransmitter Receptors Involved in their Action". Life Sciences 76 (3): 331–343. doi:10.1016/j.lfs.2004.08.012. PMID 15531384.
- ↑ Microgram Bulletin (march 2006). "DEA; Special Intelligence Brief - Kratom (Mitragyna speciosa)" (html). DEA Microgram Bulletin.
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