Racecadotril
 | |
|---|---|
| Systematic (IUPAC) name | |
| (RS)-benzyl N-[3-(acetylthio)-2-benzylpropanoyl]glycinate | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Legal status | ? |
| Routes | Oral |
| Identifiers | |
| CAS number | 81110-73-8  |
| ATC code | A07XA04 |
| PubChem | CID 107751 |
| UNII | 76K53XP4TO  |
| ChEMBL | CHEMBL1516410 |
| Synonyms | benzyl 2-[3-(acetylthio)-2-benzylpropanamido]acetate |
| Chemical data | |
| Formula | C21H23NO4S |
| Mol. mass | 385.47662 g/mol |
| (what is this?) (verify) | |
Racecadotril, also known as acetorphan, is an antidiarrheal drug which acts as a peripherally acting enkephalinase inhibitor.[1] Unlike other medications used to treat diarrhea, which reduce intestinal motility, racecadotril has an antisecretory effect—it reduces the secretion of water and electrolytes into the intestine.[2] It is available in France (where it was first introduced in 1993 and is widely used) and other European countries, as well as most of South America and some South East Asian countries, but not in the United States. It is sold under the tradenames Hidrasec or, in France, Tiorfan. In Italy it is sold under the tradename Tiorfix.
A small randomized controlled trial found racecadotril to significantly reduce the duration and volume of watery diarrhea in children when given as an adjunct to oral rehydration therapy.[3]
Thiorphan is the active metabolite of racecadotril.[4]
See also
- Ecadotril, the (S)-enantiomer of racecadotril
- D/DL-Phenylalanine
- RB-101
References
- ↑ Matheson AJ, Noble S (April 2000). "Racecadotril". Drugs 59 (4): 829–35; discussion 836–7. PMID 10804038.
- ↑ (2001) "Racecadotril: an Antidiarrhoeal Suitable for Use in Infants and Young Children". Drug Ther Perspect 17 (8): 1–5. Free full text with registration at Medscape
- ↑ Salazar-Lindo E, Santisteban-Ponce J, Chea-Woo E, Gutierrez M (2000). "Racecadotril in the treatment of acute watery diarrhea in children". N. Engl. J. Med. 343 (7): 463–7. doi:10.1056/NEJM200008173430703. PMID 10944563.
- ↑ Spillantini MG, Geppetti P, Fanciullacci M, Michelacci S, Lecomte JM, Sicuteri F (June 1986). "In vivo 'enkephalinase' inhibition by acetorphan in human plasma and CSF". European Journal of Pharmacology 125 (1): 147–50. doi:10.1016/0014-2999(86)90094-4. PMID 3015640.
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