RTI-32
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|---|---|
| Systematic (IUPAC) name | |
| methyl (1R,2S,3S,5S)-3-(4-methylphenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate | |
| Clinical data | |
| Legal status | ? |
| Identifiers | |
| CAS number | 130342-81-3 |
| ATC code | ? |
| PubChem | CID 125416 |
| Chemical data | |
| Formula | C17H23NO2 |
| Mol. mass | 273.370 g/mol |
| SMILES
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 (what is this?) (verify) | |
(–)-2β-Carbomethoxy-3β-(4-tolyl)tropane (RTI-32, tolpane) is a phenyltropane-based cocaine analog that is important in the field of medicinal chemistry for performing SAR.
It has similar properties in vitro to related drugs such as RTI-31.[1]
Whereas the potency of RTI-31 has been quoted as being as high as 64 x cocaine, RTI-32 is not anything like this strong.
| Compound | DAT | DA | NET | NA | SERT | 5HT | ED50 |
| Troparil | 23 | 49.8 | 550 | 37.2 | 178 | 173 | 0.34 |
| RTI-32 | 1.7 | 7.02 | 36 | 8.42 | 23 | 19.4 | 0.31 |
| RTI-31 | 1.1 | 3.68 | 22 | 5.86 | 4.0 | 5.0 | 0.13 |
| 3'4'-xylyl | 0.43 | unknown | 44 | unknown | 2.42 | unknown |
See also
References
- ↑ Remy P, Doder M, Lees A, Turjanski N, Brooks D. Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system. Brain. 2005 Jun;128(Pt 6):1314-22. PMID 15716302
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