RPTOR

Regulatory associated protein of MTOR, complex 1
Identifiers
Symbols	RPTOR; KOG1; Mip1
External IDs	OMIM: 607130 MGI: 1921620 HomoloGene: 80210 GeneCards: RPTOR Gene
Gene Ontology Molecular function • RNA polymerase III type 1 promoter DNA binding • RNA polymerase III type 2 promoter DNA binding • RNA polymerase III type 3 promoter DNA binding • TFIIIC-class transcription factor binding • protein binding • protein kinase binding • protein complex binding • 14-3-3 protein binding Cellular component • cytoplasm • lysosome • cytosol • TORC1 complex Biological process • cell cycle arrest • insulin receptor signaling pathway • regulation of cell size • cell growth • cellular response to nutrient levels • TOR signaling cascade • positive regulation of TOR signaling cascade • positive regulation of transcription from RNA polymerase III promoter • cellular response to amino acid stimulus • positive regulation of protein serine/threonine kinase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57521	74370
Ensembl	ENSG00000141564	ENSMUSG00000025583
UniProt	Q8N122	A2ACM0
RefSeq (mRNA)	NM_001163034	NM_028898
RefSeq (protein)	NP_001156506	NP_083174
Location (UCSC)	Chr 17: 78.52 – 78.94 Mb	Chr 11: 119.6 – 119.9 Mb
PubMed search
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Regulatory-associated protein of mTOR also known as raptor or KIAA1303 is an adapter protein that is encoded in humans by the RPTOR gene.^[1][2][3] Two mRNAs from the gene have been identified that encode proteins of 1335 (isoform 1) and 1177 (isoform 2) amino acids long.

Interactions

Raptor has been shown to interact with:

• EIF4EBP1,^{[2][4][5][6][7][8][9][10]}
• FKBP1A,^[11][12]
• P70-S6 Kinase 1^{[2][5][7][13]}
• RHEB,^[14]
• RICTOR,^[15] and
• mammalian target of rapamycin (mTOR),^{[2][4][5][6][7][11][12][15][16][17][18][19][20][21][22][23][24][25][26][27]}

References

Further reading