RPS6KB2
From Wikipedia, the free encyclopedia
Ribosomal protein S6 kinase beta-2 is an enzyme that in humans is encoded by the RPS6KB2 gene.[1][2][3]
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.[3]
References
- ↑ Saitoh M, ten Dijke P, Miyazono K, Ichijo H (Jan 1999). "Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases". Biochem Biophys Res Commun 253 (2): 470–476. doi:10.1006/bbrc.1998.9784. PMID 9878560.
- ↑ Gout I, Minami T, Hara K, Tsujishita Y, Filonenko V, Waterfield MD, Yonezawa K (Dec 1998). "Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region". J Biol Chem 273 (46): 30061–30064. doi:10.1074/jbc.273.46.30061. PMID 9804755.
- ↑ 3.0 3.1 "Entrez Gene: RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2".
Further reading
- Lee-Fruman KK, Kuo CJ, Lippincott J et al. (1999). "Characterization of S6K2, a novel kinase homologous to S6K1". Oncogene 18 (36): 5108–5114. doi:10.1038/sj.onc.1202894. PMID 10490847.
- Koh H, Jee K, Lee B et al. (1999). "Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of Akt". Oncogene 18 (36): 5115–5119. doi:10.1038/sj.onc.1202895. PMID 10490848.
- Martin KA, Schalm SS, Richardson C et al. (2001). "Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway". J. Biol. Chem. 276 (11): 7884–7891. doi:10.1074/jbc.M006969200. PMID 11108711.
- Martin KA, Schalm SS, Romanelli A et al. (2001). "Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation". J. Biol. Chem. 276 (11): 7892–7898. doi:10.1074/jbc.M009972200. PMID 11108720.
- Minami T, Hara K, Oshiro N et al. (2002). "Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha". Genes Cells 6 (11): 1003–1015. doi:10.1046/j.1365-2443.2001.00479.x. PMID 11733037.
- Pardo OE, Arcaro A, Salerno G et al. (2002). "Novel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cells". Oncogene 20 (52): 7658–7667. doi:10.1038/sj.onc.1204994. PMID 11753643.
- Park IH, Bachmann R, Shirazi H, Chen J (2002). "Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin". J. Biol. Chem. 277 (35): 31423–31429. doi:10.1074/jbc.M204080200. PMID 12087098.
- Kanayasu-Toyoda T, Yamaguchi T, Oshizawa T et al. (2002). "Role of the p70 S6 kinase cascade in neutrophilic differentiation and proliferation of HL-60 cells-a study of transferrin receptor-positive and -negative cells obtained from dimethyl sulfoxide- or retinoic acid-treated HL-60 cells". Arch. Biochem. Biophys. 405 (1): 21–31. doi:10.1016/S0003-9861(02)00330-2. PMID 12176053.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Valovka T, Verdier F, Cramer R et al. (2003). "Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization". Mol. Cell. Biol. 23 (3): 852–863. doi:10.1128/MCB.23.3.852-863.2003. PMC 140705. PMID 12529391.
- Levy Y, Ronen D, Bershadsky AD, Zick Y (2003). "Sustained induction of ERK, protein kinase B, and p70 S6 kinase regulates cell spreading and formation of F-actin microspikes upon ligation of integrins by galectin-8, a mammalian lectin". J. Biol. Chem. 278 (16): 14533–14542. doi:10.1074/jbc.M207380200. PMID 12569102.
- Phin S, Kupferwasser D, Lam J, Lee-Fruman KK (2003). "Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1". Biochem. J. 373 (Pt 2): 583–91. doi:10.1042/BJ20021794. PMC 1223513. PMID 12713446.
- Kanayasu-Toyoda T, Yamaguchi T, Oshizawa T et al. (2003). "The role of c-Myc on granulocyte colony-stimulating factor-dependent neutrophilic proliferation and differentiation of HL-60 cells". Biochem. Pharmacol. 66 (1): 133–140. doi:10.1016/S0006-2952(03)00247-8. PMID 12818373.
- An WL, Cowburn RF, Li L et al. (2003). "Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease". Am. J. Pathol. 163 (2): 591–607. doi:10.1016/S0002-9440(10)63687-5. PMC 1868198. PMID 12875979.
- Shao J, Evers BM, Sheng H (2004). "Roles of phosphatidylinositol 3'-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial cells". Cancer Res. 64 (1): 229–235. doi:10.1158/0008-5472.CAN-03-1859. PMID 14729629.
- Lekmine F, Sassano A, Uddin S et al. (2004). "Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein". Exp. Cell Res. 295 (1): 173–182. doi:10.1016/j.yexcr.2003.12.021. PMID 15051500.
- Raught B, Peiretti F, Gingras AC et al. (2005). "Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases". EMBO J. 23 (8): 1761–1769. doi:10.1038/sj.emboj.7600193. PMC 394247. PMID 15071500.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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