RPS27
From Wikipedia, the free encyclopedia
40S ribosomal protein S27 is a protein that in humans is encoded by the RPS27 gene.[1][2][3]
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S27E family of ribosomal proteins. It contains a C4-type zinc finger domain that can bind to zinc. The encoded protein has been shown to be able to bind to nucleic acid. It is located in the cytoplasm as a ribosomal component, but it has also been detected in the nucleus. Studies in rat indicate that ribosomal protein S27 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]
References
- ↑ Tsui SK, Lee SM, Fung KP, Waye MM, Lee CY (Mar 1997). "Primary structures and sequence analysis of human ribosomal proteins L39 and S27". Biochem Mol Biol Int 40 (3): 611–6. PMID 8908372.
- ↑ Fernandez-Pol JA, Klos DJ, Hamilton PD (Nov 1993). "A growth factor-inducible gene encodes a novel nuclear protein with zinc finger structure". J Biol Chem 268 (28): 21198–204. PMID 8407955.
- ↑ 3.0 3.1 "Entrez Gene: RPS27 ribosomal protein S27 (metallopanstimulin 1)".
Further reading
- Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
- Fernandez-Pol JA, Klos DJ, Hamilton PD (1995). "Metallopanstimulin gene product produced in a baculovirus expression system is a nuclear phosphoprotein that binds to DNA". Cell Growth Differ. 5 (8): 811–25. PMID 7986747.
- Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
- Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
- Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
- Atsuta Y, Aoki N, Sato K, et al. (2002). "Identification of metallopanstimulin-1 as a member of a tumor associated antigen in patients with breast cancer". Cancer Lett. 182 (1): 101–7. doi:10.1016/S0304-3835(02)00068-X. PMID 12175529.
- Martin-Lluesma S, Stucke VM, Nigg EA (2002). "Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2". Science 297 (5590): 2267–70. doi:10.1126/science.1075596. PMID 12351790.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Liu ST, Chan GK, Hittle JC, et al. (2003). "Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores". Mol. Biol. Cell 14 (4): 1638–51. doi:10.1091/mbc.02-05-0074. PMC 153128. PMID 12686615.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
- Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Bhonde MR, Hanski ML, Budczies J, et al. (2006). "DNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: the lack of this suppression in p53MUT cells contributes to apoptosis". J. Biol. Chem. 281 (13): 8675–85. doi:10.1074/jbc.M511333200. PMID 16446370.
- Wang YW, Qu Y, Li JF, et al. (2006). "In vitro and in vivo evidence of metallopanstimulin-1 in gastric cancer progression and tumorigenicity". Clin. Cancer Res. 12 (16): 4965–73. doi:10.1158/1078-0432.CCR-05-2316. PMID 16914586.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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