RPS10

From Wikipedia, the free encyclopedia
Ribosomal protein S10
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsRPS10; DBA9; S10
External IDsOMIM: 603632 MGI: 1914347 HomoloGene: 133068 GeneCards: RPS10 Gene
Orthologs
SpeciesHumanMouse
Entrez620467097
EnsemblENSG00000124614ENSMUSG00000052146
UniProtP46783P63325
RefSeq (mRNA)NM_001014NM_025963.3
RefSeq (protein)NP_001005NP_080239.1
Location (UCSC)Chr 6:
34.39 – 34.39 Mb
Chr 17:
27.63 – 27.64 Mb
PubMed search

40S ribosomal protein S10 is a protein that in humans is encoded by the RPS10 gene.[1][2][3]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]

Clinical significance

Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found.[3]

Interactions

RPS10 has been shown to interact with PTTG1.[4]

References

  1. Frigerio JM, Dagorn JC, Iovanna JL (Jul 1995). "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochim Biophys Acta 1262 (1): 64–8. PMID 7772601. 
  2. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194. 
  3. 3.0 3.1 3.2 "Entrez Gene: RPS10 ribosomal protein S10". 
  4. Pei, L (Jan 1999). "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells". J. Biol. Chem. (UNITED STATES) 274 (5): 3151–8. doi:10.1074/jbc.274.5.3151. ISSN 0021-9258. PMID 9915854. 

Further reading

External links


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