RNF25

From Wikipedia, the free encyclopedia

Ring finger protein 25

PDB rendering based on 2day.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2DAY, 2DMF

Identifiers

RNF25; AO7

External IDs

MGI: 1890215 HomoloGene: 11193 GeneCards: RNF25 Gene

Gene Ontology
Molecular function	• ubiquitin-protein ligase activity • zinc ion binding • NF-kappaB binding
Cellular component	• nucleus • cytosol
Biological process	• protein ubiquitination • positive regulation of NF-kappaB transcription factor activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000163481

ENSMUSG00000026171

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
219.53 – 219.54 Mb

Chr 1:
74.59 – 74.6 Mb

PubMed search

E3 ubiquitin-protein ligase RNF25 is an enzyme that in humans is encoded by the RNF25 gene.^[1]^[2]

The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination.^[2]

Interactions

RNF25 has been shown to interact with RELA.^[1]

References

↑ 1.0 1.1 Asamitsu K, Tetsuka T, Kanazawa S, Okamoto T (Jul 2003). "RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit". J Biol Chem 278 (29): 26879–87. doi:10.1074/jbc.M211831200. PMID 12748188.
↑ 2.0 2.1 "Entrez Gene: RNF25 ring finger protein 25".

Further reading

Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lorick KL, Jensen JP, Fang S et al. (1999). "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11364–9. doi:10.1073/pnas.96.20.11364. PMC 18039. PMID 10500182.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

PDB gallery

2day: Solution structure of the RWD domain of human ring finger protein 25

2dmf: An extended conformation of the RWD domain of human Ring finger protein 25

This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.