RNF146

From Wikipedia, the free encyclopedia

Ring finger protein 146

PDB rendering based on 1ujr.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2D8T, 3V3L

Identifiers

RNF146; RP3-351K20.1; dJ351K20.1

External IDs

OMIM: 612137 MGI: 1915281 HomoloGene: 12227 GeneCards: RNF146 Gene

Gene Ontology
Molecular function	• ubiquitin-protein ligase activity • protein binding • zinc ion binding • poly-ADP-D-ribose binding
Cellular component	• nucleus • cytosol
Biological process	• Wnt receptor signaling pathway • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • protein autoubiquitination • protein K48-linked ubiquitination • positive regulation of canonical Wnt receptor signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000118518

ENSMUSG00000038876

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
127.59 – 127.61 Mb

Chr 10:
29.34 – 29.36 Mb

PubMed search

RING finger protein 146 is a protein that in humans is encoded by the RNF146 gene.^[1]

References

↑ "Entrez Gene: RNF146 ring finger protein 146".

Further reading

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
von Rotz RC, Kins S, Hipfel R, et al. (2005). "The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease.". Eur. J. Neurosci. 21 (5): 1289–98. doi:10.1111/j.1460-9568.2005.03977.x. PMID 15813938.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

PDB gallery

1ujr: Solution structure of WWE domain in BAB28015

2d8t: Solution structure of the RING domain of the human RING finger protein 146

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