RNF125

From Wikipedia, the free encyclopedia

Ring finger protein 125, E3 ubiquitin protein ligase

Identifiers

RNF125; TRAC-1; TRAC1

External IDs

OMIM: 610432 HomoloGene: 32369 GeneCards: RNF125 Gene

Gene Ontology
Molecular function	• ubiquitin-protein ligase activity • zinc ion binding
Cellular component	• intracellular
Biological process	• negative regulation of type I interferon production • innate immune response
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

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ENSG00000101695

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RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)

Chr 18:
29.6 – 29.65 Mb

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PubMed search

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E3 ubiquitin-protein ligase RNF125 is an enzyme that in humans is encoded by the RNF125 gene.^[1]

This gene encodes a novel E3 ubiquitin ligase that contains an N-terminal RING finger domain. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway.^[1]

References

↑ 1.0 1.1 "Entrez Gene: RNF125 ring finger protein 125".

Further reading

Giannini AL, Gao Y, Bijlmakers MJ (2008). "T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain.". Biochem. J. 410 (1): 101–11. doi:10.1042/BJ20070995. PMC 2733222. PMID 17990982.
Shoji-Kawata S, Zhong Q, Kameoka M, et al. (2007). "The RING finger ubiquitin ligase RNF125/TRAC-1 down-modulates HIV-1 replication in primary human peripheral blood mononuclear cells.". Virology 368 (1): 191–204. doi:10.1016/j.virol.2007.06.028. PMID 17643463.
Zhao H, Li CC, Pardo J, et al. (2005). "A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation.". J. Immunol. 174 (9): 5288–97. PMID 15843525.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Chu P, Pardo J, Zhao H, et al. (2004). "Systematic identification of regulatory proteins critical for T-cell activation.". J. Biol. 2 (3): 21. doi:10.1186/1475-4924-2-21. PMC 333404. PMID 12974981.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Saurin AJ, Borden KL, Boddy MN, Freemont PS (1996). "Does this have a familiar RING?". Trends Biochem. Sci. 21 (6): 208–14. PMID 8744354.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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