RNF12

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Ring finger protein, LIM domain interacting
Identifiers
SymbolsRLIM; NY-REN-43; RNF12
External IDsOMIM: 300379 MGI: 1342291 HomoloGene: 7920 GeneCards: RLIM Gene
Orthologs
SpeciesHumanMouse
Entrez5113219820
EnsemblENSG00000131263ENSMUSG00000056537
UniProtQ9NVW2Q9WTV7
RefSeq (mRNA)NM_016120NM_011276
RefSeq (protein)NP_057204NP_035406
Location (UCSC)Chr X:
73.81 – 73.83 Mb		Chr X:
103.96 – 103.98 Mb
PubMed search
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E3 ubiquitin-protein ligase RLIM is an enzyme that in humans is encoded by the RLIM gene.[1][2]

The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be a ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Alternatively spliced transcript variants encoding the same protein have been reported.[2]

Interactions

RNF12 has been shown to interact with Estrogen receptor alpha.[3]

References

  1. ↑ Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jager D, Jager E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int J Cancer 83 (4): 456–464. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479. 
  2. ↑ 2.0 2.1 "Entrez Gene: RNF12 ring finger protein 12". 
  3. ↑ Johnsen, Steven A; Güngör Cenap, Prenzel Tanja, Riethdorf Sabine, Riethdorf Lutz, Taniguchi-Ishigaki Naoko, Rau Thomas, Tursun Baris, Furlow J David, Sauter Guido, Scheffner Martin, Pantel Klaus, Gannon Frank, Bach Ingolf (Jan 2009). "Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer". Cancer Res. (United States) 69 (1): 128–136. doi:10.1158/0008-5472.CAN-08-1630. PMC 2713826. PMID 19117995. 

Further reading

  • Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514. 
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039. 
  • Hiratani I, Yamamoto N, Mochizuki T et al. (2003). "Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions". Development 130 (17): 4161–4175. doi:10.1242/dev.00621. PMID 12874135. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Ostendorff HP, Peirano RI, Peters MA et al. (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors". Nature 416 (6876): 99–103. doi:10.1038/416099a. PMID 11882901. 
  • Ostendorff HP, Bossenz M, Mincheva A et al. (2001). "Functional characterization of the gene encoding RLIM, the corepressor of LIM homeodomain factors". Genomics 69 (1): 120–130. doi:10.1006/geno.2000.6311. PMID 11013082. 
  • Bach I, Rodriguez-Esteban C, Carrière C et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–399. doi:10.1038/11970. PMID 10431247. 


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