RNF111
From Wikipedia, the free encyclopedia
E3 ubiquitin-protein ligase Arkadia is an enzyme that in humans is encoded by the RNF111 gene.[1][2]
The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development.[2]
Interactions
RNF111 has been shown to interact with Mothers against decapentaplegic homolog 7[3] and Mothers against decapentaplegic homolog 3.[3][4]
References
- ↑ Episkopou V, Arkell R, Timmons PM, Walsh JJ, Andrew RL, Swan D (Apr 2001). "Induction of the mammalian node requires Arkadia function in the extraembryonic lineages". Nature 410 (6830): 825–30. doi:10.1038/35071095. PMID 11298452.
- ↑ 2.0 2.1 "Entrez Gene: RNF111 ring finger protein 111".
- ↑ 3.0 3.1 Koinuma, Daizo; Shinozaki Masahiko, Komuro Akiyoshi, Goto Kouichiro, Saitoh Masao, Hanyu Aki, Ebina Masahito, Nukiwa Toshihiro, Miyazawa Keiji, Imamura Takeshi, Miyazono Kohei (Dec 2003). "Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7". EMBO J. (England) 22 (24): 6458–70. doi:10.1093/emboj/cdg632. ISSN 0261-4189. PMC 291827. PMID 14657019.
- ↑ Yuzawa, Hisanori; Koinuma Daizo, Maeda Shingo, Yamamoto Kengo, Miyazawa Keiji, Imamura Takeshi (Jan 2009). "Arkadia represses the expression of myoblast differentiation markers through degradation of Ski and the Ski-bound Smad complex in C2C12 myoblasts". Bone (United States) 44 (1): 53–60. doi:10.1016/j.bone.2008.09.013. PMID 18950738.
Further reading
- Patten I, Placzek M (2001). "Vertebrate development: Et in Arkadia". Curr. Biol. 11 (15): R616–9. doi:10.1016/S0960-9822(01)00367-0. PMID 11516970.
- Niederländer C, Walsh JJ, Episkopou V, Jones CM (2001). "Arkadia enhances nodal-related signalling to induce mesendoderm". Nature 410 (6830): 830–4. doi:10.1038/35071103. PMID 11298453.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Koinuma D, Shinozaki M, Komuro A, et al. (2004). "Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7". EMBO J. 22 (24): 6458–70. doi:10.1093/emboj/cdg632. PMC 291827. PMID 14657019.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Liu W, Rui H, Wang J, et al. (2006). "Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia". EMBO J. 25 (8): 1646–58. doi:10.1038/sj.emboj.7601057. PMC 1440825. PMID 16601693.
- Nagano Y, Mavrakis KJ, Lee KL, et al. (2007). "Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling". J. Biol. Chem. 282 (28): 20492–501. doi:10.1074/jbc.M701294200. PMID 17510063.
- Levy L, Howell M, Das D, et al. (2007). "Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation". Mol. Cell. Biol. 27 (17): 6068–83. doi:10.1128/MCB.00664-07. PMC 1952153. PMID 17591695.
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