RNF11
From Wikipedia, the free encyclopedia
| Ring finger protein 11 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | RNF11; SID1669 | ||||||||||||
| External IDs | OMIM: 612598 MGI: 1352759 HomoloGene: 32195 GeneCards: RNF11 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 26994 | 29864 | |||||||||||
| Ensembl | ENSG00000123091 | ENSMUSG00000028557 | |||||||||||
| UniProt | Q9Y3C5 | Q9QYK7 | |||||||||||
| RefSeq (mRNA) | NM_014372 | NM_013876 | |||||||||||
| RefSeq (protein) | NP_055187 | NP_038904 | |||||||||||
| Location (UCSC) | Chr 1: 51.7 – 51.74 Mb | Chr 4: 109.45 – 109.48 Mb | |||||||||||
| PubMed search | |||||||||||||
RING finger protein 11 is a protein that in humans is encoded by the RNF11 gene.[1][2][3]
The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).[3]
See also
Interactions
RNF11 has been shown to interact with RIPK1[4] and STAMBP.[5]
References
- ↑ Seki N, Hattori A, Hayashi A, Kozuma S, Sasaki M, Suzuki Y, Sugano S, Muramatsu MA, Saito T (March 2000). "Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein". Biochim Biophys Acta 1489 (2–3): 421–7. PMID 10673045.
- ↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (August 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
- ↑ 3.0 3.1 "Entrez Gene: RNF11 ring finger protein 11".
- ↑ Shembade, Noula; Parvatiyar Kislay, Harhaj Nicole S, Harhaj Edward W (March 2009). "The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling". EMBO J. (England) 28 (5): 513–22. doi:10.1038/emboj.2008.285. PMC 2657574. PMID 19131965.
- ↑ Li, Haoxia; Seth Arun (March 2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene (England) 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. ISSN 0950-9232. PMID 14755250.
Further reading
- Burger A, Amemiya Y, Kitching R, Seth AK (2006). "Novel RING E3 ubiquitin ligases in breast cancer". Neoplasia 8 (8): 689–95. doi:10.1593/neo.06469. PMC 1601945. PMID 16925951.
- Jolliffe CN, Harvey KF, Haines BP, et al. (2001). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". Biochem. J. 351 Pt 3: 557–65. PMC 1221394. PMID 11042109.
- Watanabe T, Ichihara M, Hashimoto M, et al. (2002). "Characterization of gene expression induced by RET with MEN2A or MEN2B mutation". Am. J. Pathol. 161 (1): 249–56. doi:10.1016/S0002-9440(10)64176-4. PMC 1850689. PMID 12107109.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kitching R, Wong MJ, Koehler D, et al. (2003). "The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases". Biochim. Biophys. Acta 1639 (2): 104–12. PMID 14559117.
- Subramaniam V, Li H, Wong M, et al. (2003). "The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase". Br. J. Cancer 89 (8): 1538–44. doi:10.1038/sj.bjc.6601301. PMC 2394340. PMID 14562029.
- Li H, Seth A (2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Connor MK, Azmi PB, Subramaniam V, et al. (2005). "Molecular characterization of ring finger protein 11". Mol. Cancer Res. 3 (8): 453–61. doi:10.1158/1541-7786.MCR-04-0166. PMID 16123141.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Anderson LR, Betarbet R, Gearing M, et al. (2007). "PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain". J. Neuropathol. Exp. Neurol. 66 (10): 955–64. doi:10.1097/nen.0b013e3181567f17. PMID 17917589.
External links
- RNF11 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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