RMI1

From Wikipedia, the free encyclopedia

RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)

Rendering based on PDB 3MXN.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3MXN, 3NBH, 3NBI, 4DAY

Identifiers

RMI1; BLAP75; C9orf76; FAAP75; RP11-346I8.1

External IDs

OMIM: 610404 MGI: 1921636 HomoloGene: 41601 GeneCards: RMI1 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• nucleus
Biological process	• DNA replication
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000178966

ENSMUSG00000035367

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 9:
86.6 – 86.62 Mb

Chr 13:
58.4 – 58.41 Mb

PubMed search

RecQ-mediated genome instability protein 1 is a protein that in humans is encoded by the RMI1 gene.^[1]^[2]

References

↑ Yin J, Sobeck A, Xu C, Meetei AR, Hoatlin M, Li L, Wang W (May 2005). "BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity". EMBO J 24 (7): 1465–76. doi:10.1038/sj.emboj.7600622. PMC 1142546. PMID 15775963.
↑ "Entrez Gene: RMI1 RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)".

Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Meetei AR, de Winter JP, Medhurst AL, et al. (2003). "A novel ubiquitin ligase is deficient in Fanconi anemia". Nat. Genet. 35 (2): 165–70. doi:10.1038/ng1241. PMID 12973351.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wu L, Bachrati CZ, Ou J, et al. (2006). "BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates". Proc. Natl. Acad. Sci. U.S.A. 103 (11): 4068–73. doi:10.1073/pnas.0508295103. PMC 1449647. PMID 16537486.
Raynard S, Bussen W, Sung P (2006). "A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75". J. Biol. Chem. 281 (20): 13861–4. doi:10.1074/jbc.C600051200. PMID 16595695.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Bussen W, Raynard S, Busygina V, et al. (2007). "Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex". J. Biol. Chem. 282 (43): 31484–92. doi:10.1074/jbc.M706116200. PMID 17728255.
Broberg K, Höglund M, Gustafsson C, et al. (2008). "Genetic variant of the human homologous recombination-associated gene RMI1 (S455N) impacts the risk of AML/MDS and malignant melanoma". Cancer Lett. 258 (1): 38–44. doi:10.1016/j.canlet.2007.08.005. PMID 17900800.

This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.