RIT2

From Wikipedia, the free encyclopedia

Ras-like without CAAX 2

Identifiers

RIT2; RIBA; RIN; ROC2

External IDs

OMIM: 609592 MGI: 108054 HomoloGene: 2198 GeneCards: RIT2 Gene

Gene Ontology
Molecular function	• GTPase activity • calmodulin binding • GTP binding
Cellular component	• nucleus • plasma membrane
Biological process	• signal transduction • small GTPase mediated signal transduction • synaptic transmission • neurotrophin TRK receptor signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000152214

ENSMUSG00000057455

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 18:
40.32 – 40.7 Mb

Chr 18:
30.97 – 31.32 Mb

PubMed search

GTP-binding protein Rit2 is a protein that in humans is encoded by the RIT2 gene.^[1]^[2]^[3]

RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999).[supplied by OMIM]^[3]

Interactions

RIT2 has been shown to interact with POU4F1.^[4]

References

↑ Lee CH, Della NG, Chew CE, Zack DJ (Nov 1996). "Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins". J Neurosci 16 (21): 6784–94. PMID 8824319.
↑ Wes PD, Yu M, Montell C (Jan 1997). "RIC, a calmodulin-binding Ras-like GTPase". EMBO J 15 (21): 5839–48. PMC 452332. PMID 8918462.
↑ 3.0 3.1 "Entrez Gene: RIT2 Ras-like without CAAX 2".
↑ Calissano, M; Latchman D S (Aug 2003). "Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor". Oncogene (England) 22 (35): 5408–14. doi:10.1038/sj.onc.1206635. ISSN 0950-9232. PMID 12934100. Cite uses deprecated parameters (help)

Further reading

Shao H, Kadono-Okuda K, Finlin BS, Andres DA (1999). "Biochemical characterization of the Ras-related GTPases Rit and Rin.". Arch. Biochem. Biophys. 371 (2): 207–19. doi:10.1006/abbi.1999.1448. PMID 10545207.
Hoshino M, Nakamura S (2002). "The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation.". Biochem. Biophys. Res. Commun. 295 (3): 651–6. doi:10.1016/S0006-291X(02)00731-3. PMID 12099688.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Calissano M, Latchman DS (2003). "Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor.". Oncogene 22 (35): 5408–14. doi:10.1038/sj.onc.1206635. PMID 12934100.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hartwig C, Veske A, Krejcova S, et al. (2006). "Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin.". BMC neuroscience 6: 53. doi:10.1186/1471-2202-6-53. PMC 1215486. PMID 16122393.
Shi GX, Han J, Andres DA (2006). "Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation.". J. Biol. Chem. 280 (45): 37599–609. doi:10.1074/jbc.M507364200. PMID 16157584.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

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