RHBDF1
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| Rhomboid 5 homolog 1 (Drosophila) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | RHBDF1; C16orf8; Dist1; EGFR-RS; gene-89; gene-90; hDist1 | ||||||||||||
| External IDs | OMIM: 614403 MGI: 104328 HomoloGene: 32085 GeneCards: RHBDF1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 64285 | 13650 | |||||||||||
| Ensembl | ENSG00000007384 | ENSMUSG00000020282 | |||||||||||
| UniProt | Q96CC6 | Q6PIX5 | |||||||||||
| RefSeq (mRNA) | NM_022450 | NM_010117 | |||||||||||
| RefSeq (protein) | NP_071895 | NP_034247 | |||||||||||
| Location (UCSC) | Chr 16: 0.11 – 0.13 Mb | Chr 11: 32.21 – 32.22 Mb | |||||||||||
| PubMed search | |||||||||||||
Inactive rhomboid protein 1 (iRhom1) also known as rhomboid 5 homolog 1 or rhomboid family member 1 (RHBDF1) is a protein that in humans is encoded by the RHBDF1 gene.[1][2][3] The alternative name iRhom1 has been proposed, in order to clarify that it is a catalytically inactive member of the rhomboid family of intramembrane serine proteases.[4][5]
References
- ↑ Kielman MF, Smits R, Devi TS, Fodde R, Bernini LF (Aug 1993). "Homology of a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse". Mamm Genome 4 (6): 314–323. doi:10.1007/BF00357090. PMID 8318735.
- ↑ Nakagawa T, Guichard A, Castro CP, Xiao Y, Rizen M, Zhang HZ, Hu D, Bang A, Helms J, Bier E, Derynck R (Jul 2005). "Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands". Dev Dyn 233 (4): 1315–1331. doi:10.1002/dvdy.20450. PMID 15965977.
- ↑ "Entrez Gene: RHBDF1 rhomboid 5 homolog 1 (Drosophila)".
- ↑ Lemberg MK, Freeman M (November 2007). "Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases". Genome Res. 17 (11): 1634–46. doi:10.1101/gr.6425307. PMC 2045146. PMID 17938163.
- ↑ Zettl M, Adrain C, Strisovsky K, Lastun V, Freeman M (April 2011). "Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling". Cell 145 (1): 79–91. doi:10.1016/j.cell.2011.02.047. PMID 21439629.
Further reading
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Daniels RJ, Peden JF, Lloyd C et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–352. doi:10.1093/hmg/10.4.339. PMID 11157797.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Flint J, Thomas K, Micklem G et al. (1997). "The relationship between chromosome structure and function at a human telomeric region". Nat. Genet. 15 (3): 252–257. doi:10.1038/ng0397-252. PMID 9054936.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
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