RGS8

From Wikipedia, the free encyclopedia

Regulator of G-protein signaling 8

PDB rendering based on 2ihd.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2IHD, 2ODE

Identifiers

Symbols

RGS8; MGC119067; MGC119068; MGC119069

External IDs

OMIM: 607189 HomoloGene: 23152 GeneCards: RGS8 Gene

Gene Ontology
Molecular function	• GTPase activator activity
Cellular component	• cytoplasm • plasma membrane
Biological process	• termination of G-protein coupled receptor signaling pathway • positive regulation of GTPase activity
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
182.62 – 182.65 Mb

Chr 1:
153.65 – 153.7 Mb

PubMed search

Regulator of G-protein signaling 8 is a protein that in humans is encoded by the RGS8 gene.^[1]^[2]

This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation.^[2]

References

↑ Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, Morgenbesser SD, Su K, Faruque MU, Pinkett H, Graham C, Baxevanis AD, Klinger KW, Landes GM, Trent JM, Carpten JD (Apr 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
↑ 2.0 2.1 "Entrez Gene: RGS8 regulator of G-protein signalling 8".

Berman DM, Wilkie TM, Gilman AG (1996). "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits". Cell 86 (3): 445–452. doi:10.1016/S0092-8674(00)80117-8. PMID 8756726.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
Luo X, Popov S, Bera AK, Wilkie TM, Muallem S (2001). "RGS proteins provide biochemical control of agonist-evoked [Ca2+]i oscillations". Molecular Cell 7 (3): 651–660. doi:10.1016/S1097-2765(01)00211-8. PMID 11463389.
Pashkov V, Huang J, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Esser V, Gerard RD, Uyeda K, Towle HC, Wilkie TM (2011). "Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner". J Biol Chem 286 (17): 15116–15125. doi:10.1074/jbc.M110.216234. PMID 21357625.
Popov S, Yu K, Kozasa T, Wilkie TM (1997). "The regulators of G protein signaling (RGS) domains of RGS4, RGS10 and GAIP retain GTPase activating protein activity in vitro". Proc Natl Acad Sci USA 94 (14): 7216–20. doi:10.1073/pnas.94.14.7216. PMC 23796. PMID 9207071.
Popov SG, Krishna UM, Falck JR, Wilkie TM (2000). "Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity". J Biol Chem 275 (25): 18962–8. doi:10.1074/jbc.M001128200. PMID 10747990.
Ross EM, Wilkie TM (2000). "GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins.". Annual Review Biochemistry 69: 795–827. doi:10.1146/annurev.biochem.69.1.795. PMID 10966476.
Saitoh O, Murata Y, Odagiri M, et al. (2002). "Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling.". Proc. Natl. Acad. Sci. U.S.A. 99 (15): 10138–43. doi:10.1073/pnas.152085999. PMC 126637. PMID 12110731.
Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, Barker SA, He W, Wensel TG, Otero G, Brown G, Copeland NG, Jenkins NA, Wilkie TM (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human.". Genomics 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Masuho I, Itoh M, Itoh H, Saitoh O (2004). "The mechanism of membrane-translocation of regulator of G-protein signaling (RGS) 8 induced by Galpha expression.". J. Neurochem. 88 (1): 161–8. doi:10.1046/j.1471-4159.2003.02139.x. PMID 14675160.
Larminie C, Murdock P, Walhin JP, et al. (2004). "Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system.". Brain Res. Mol. Brain Res. 122 (1): 24–34. doi:10.1016/j.molbrainres.2003.11.014. PMID 14992813.
Saitoh O, Yoshihiro K (2005). "Biochemical and electrophysiological analyses of RGS8 function.". Meth. Enzymol. 390: 129–48. doi:10.1016/S0076-6879(04)90009-2. PMID 15488175.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Benians A, Nobles M, Tinker A (2005). "Participation of RGS8 in the ternary complex of agonist, receptor and G-protein.". Biochem. Soc. Trans. 32 (Pt 6): 1045–7. doi:10.1042/BST0321045. PMID 15506959.
Benians A, Nobles M, Hosny S, Tinker A (2005). "Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics.". J. Biol. Chem. 280 (14): 13383–94. doi:10.1074/jbc.M410163200. PMID 15677457.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Villasenor A, Wang ZV, Rivera LB, Ocal O, Asterholm IW, Scherer PE, Brekken RA, Cleaver O, Wilkie TM (2010). "Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes". Disease Models & Mechanisms 3 (9-10): 567–580. doi:10.1242/dmm.003210. PMID 20616094.
Wilkie TM, Kinch L (2005). "New roles for Galpha and RGS proteins: communication continues despite pulling sisters apart". Current Biology 15 (20): R843–54. doi:10.1016/j.cub.2005.10.008. PMID 16243026.

PDB gallery

2ihd: Crystal structure of Human Regulator of G-protein signaling 8, RGS8

2ode: Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3

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RGS8

References

Further reading