RGS18
From Wikipedia, the free encyclopedia
| Regulator of G-protein signaling 18 | |||||||||||||
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 PDB rendering based on 2dlv. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | RGS18; RGS13 | ||||||||||||
| External IDs | OMIM: 607192 MGI: 1927498 HomoloGene: 11281 GeneCards: RGS18 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 64407 | 64214 | |||||||||||
| Ensembl | ENSG00000150681 | ENSMUSG00000026357 | |||||||||||
| UniProt | Q9NS28 | Q99PG4 | |||||||||||
| RefSeq (mRNA) | NM_130782 | NM_022881 | |||||||||||
| RefSeq (protein) | NP_570138 | NP_075019 | |||||||||||
| Location (UCSC) | Chr 1: 192.13 – 192.15 Mb | Chr 1: 144.75 – 144.78 Mb | |||||||||||
| PubMed search | |||||||||||||
Regulator of G-protein signaling 18 is a protein that in humans is encoded by the RGS18 gene.[1][2]
This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[2]
Interactions
RGS18 has been shown to interact with GNAI3.[3][4]
References
- ↑ Park IK, Klug CA, Li K, Jerabek L, Li L, Nanamori M, Neubig RR, Hood L, Weissman IL, Clarke MF (March 2001). "Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells". J Biol Chem 276 (2): 915–23. doi:10.1074/jbc.M005947200. PMID 11042171.
- ↑ 2.0 2.1 "Entrez Gene: RGS18 regulator of G-protein signalling 18".
- ↑ Yowe, D; Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie T M, Gutierrez-Ramos C, Hodge M R (October 2001). "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". Biochem. J. (England) 359 (Pt 1): 109–18. doi:10.1042/0264-6021:3590109. ISSN 0264-6021. PMC 1222126. PMID 11563974.
- ↑ Gagnon, Alison W; Murray David L, Leadley Robert J (July 2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cell. Signal. (England) 14 (7): 595–606. doi:10.1016/S0898-6568(02)00012-8. ISSN 0898-6568. PMID 11955952.
Further reading
- Nagata Y, Oda M, Nakata H, et al. (2001). "A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes". Blood 97 (10): 3051–60. doi:10.1182/blood.V97.10.3051. PMID 11342430.
- Yowe D, Weich N, Prabhudas M, et al. (2003). "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". Biochem. J. 359 (Pt 1): 109–18. doi:10.1042/0264-6021:3590109. PMC 1222126. PMID 11563974.
- Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488.
- Gagnon AW, Murray DL, Leadley RJ (2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cell. Signal. 14 (7): 595–606. doi:10.1016/S0898-6568(02)00012-8. PMID 11955952.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Larminie C, Murdock P, Walhin JP, et al. (2004). "Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system". Brain Res. Mol. Brain Res. 122 (1): 24–34. doi:10.1016/j.molbrainres.2003.11.014. PMID 14992813.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Aldenhoven J, Chen Y, Moran C (2006). "Assignment of UCK2, ATF3 and RGS18 from human chromosome 1 to porcine chromosomes 4, 9 and 10 with somatic and radiation hybrid panels". Cytogenet. Genome Res. 112 (3–4): 341F. doi:10.1159/000089896. PMID 16484797.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
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