RGS13
| Regulator of G-protein signaling 13 | |||||||||||||
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| Symbols | RGS13; MGC17173 | ||||||||||||
| External IDs | OMIM: 607190 MGI: 2180585 HomoloGene: 14774 GeneCards: RGS13 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 6003 | 246709 | |||||||||||
| Ensembl | ENSG00000127074 | ENSMUSG00000051079 | |||||||||||
| UniProt | O14921 | Q8K443 | |||||||||||
| RefSeq (mRNA) | NM_002927 | NM_153171 | |||||||||||
| RefSeq (protein) | NP_002918 | NP_694811 | |||||||||||
| Location (UCSC) | Chr 1: 192.61 – 192.63 Mb | Chr 1: 144.14 – 144.18 Mb | |||||||||||
| PubMed search | |||||||||||||
Regulator of G-protein signaling 13 is a protein that in humans is encoded by the RGS13 gene.[1][2]
RGS 13 is a member of R4 subfamily of RGS (Regualtors of G Protein Signaling) proteins which have only short peptide sequences flanking the RGS domain. RGS 13 suppresses the immunoglobulin E- mediated allergic responses.[3]
The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.[2]
References
- ↑ Johnson EN, Druey KM (May 2002). "Functional characterization of the G protein regulator RGS13". J Biol Chem 277 (19): 16768–16774. doi:10.1074/jbc.M200751200. PMID 11875076.
- ↑ 2.0 2.1 "Entrez Gene: RGS13 regulator of G-protein signalling 13".
- ↑ Bansal G, Xie Z, Rao S, Nocka KH, Druey KM (2008). "Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13". Nat. Immunol. 9 (1): 73–80. doi:10.1038/ni1533. PMC 2387203. PMID 18026105.
Further reading
- Gregory SG, Barlow KF, McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–321. doi:10.1038/nature04727. PMID 16710414.
- Han JI, Huang NN, Kim DU, Kehrl JH (2006). "RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization". J. Leukoc. Biol. 79 (6): 1357–1368. doi:10.1189/jlb.1105693. PMID 16565322.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Islam TC, Asplund AC, Lindvall JM et al. (2003). "High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma". Leukemia 17 (9): 1880–1890. doi:10.1038/sj.leu.2403057. PMID 12970790.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Sierra DA, Gilbert DJ, Householder D et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics 79 (2): 177–185. doi:10.1006/geno.2002.6693. PMID 11829488.
- Druey KM, Blumer KJ, Kang VH, Kehrl JH (1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family". Nature 379 (6567): 742–746. doi:10.1038/379742a0. PMID 8602223.