RGS11
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| Regulator of G-protein signaling 11 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | RGS11; RS11 | ||||||||||||
| External IDs | OMIM: 603895 MGI: 1354739 HomoloGene: 77719 GeneCards: RGS11 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8786 | 50782 | |||||||||||
| Ensembl | ENSG00000076344 | ENSMUSG00000024186 | |||||||||||
| UniProt | O94810 | G3X8W6 | |||||||||||
| RefSeq (mRNA) | NM_003834 | NM_001081069 | |||||||||||
| RefSeq (protein) | NP_003825 | NP_001074538 | |||||||||||
| Location (UCSC) | Chr 16: 0.32 – 0.33 Mb | Chr 17: 26.2 – 26.21 Mb | |||||||||||
| PubMed search | |||||||||||||
Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene.[1][2]
The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.[2]
References
- ↑ Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (Nov 1998). "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits". Proc Natl Acad Sci U S A 95 (22): 13307–12. doi:10.1073/pnas.95.22.13307. PMC 23793. PMID 9789084.
- ↑ 2.0 2.1 "Entrez Gene: RGS11 regulator of G-protein signalling 11".
Further reading
- Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16.". Nature 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human.". Genomics 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488.
- Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
- Snow BE, Betts L, Mangion J, et al. (1999). "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. doi:10.1073/pnas.96.11.6489. PMC 26909. PMID 10339615.
- Gold SJ, Ni YG, Dohlman HG, Nestler EJ (1997). "Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain.". J. Neurosci. 17 (20): 8024–37. PMID 9315921.
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