RFWD2
From Wikipedia, the free encyclopedia
| Ring finger and WD repeat domain 2, E3 ubiquitin protein ligase | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | RFWD2; COP1; RNF200 | ||||||||||||
| External IDs | OMIM: 608067 HomoloGene: 115565 GeneCards: RFWD2 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 64326 | 26374 | |||||||||||
| Ensembl | ENSG00000143207 | ENSMUSG00000040782 | |||||||||||
| UniProt | Q8NHY2 | Q9R1A8 | |||||||||||
| RefSeq (mRNA) | NM_001001740 | NM_011931 | |||||||||||
| RefSeq (protein) | NP_001001740 | NP_036061 | |||||||||||
| Location (UCSC) | Chr 1: 175.91 – 176.18 Mb | Chr 1: 159.23 – 159.35 Mb | |||||||||||
| PubMed search | |||||||||||||
E3 ubiquitin-protein ligase RFWD2 is an enzyme that in humans is encoded by the RFWD2 gene.[1][2]
Interactions
RFWD2 has been shown to interact with C-jun.[3][4]
References
- ↑ Wang H, Kang D, Deng XW, Wei N (Sep 1999). "Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1". Curr Biol 9 (13): 711–4. doi:10.1016/S0960-9822(99)80314-5. PMID 10395541.
- ↑ "Entrez Gene: RFWD2 ring finger and WD repeat domain 2".
- ↑ Wertz, Ingrid E; O'Rourke Karen M, Zhang Zemin, Dornan David, Arnott David, Deshaies Raymond J, Dixit Vishva M (Feb 2004). "Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase". Science (United States) 303 (5662): 1371–4. doi:10.1126/science.1093549. PMID 14739464.
- ↑ Bianchi, Elisabetta; Denti Simona, Catena Raffaella, Rossetti Grazisa, Polo Simona, Gasparian Sona, Putignano Stella, Rogge Lars, Pardi Ruggero (May 2003). "Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity". J. Biol. Chem. (United States) 278 (22): 19682–90. doi:10.1074/jbc.M212681200. ISSN 0021-9258. PMID 12615916.
Further reading
- Hoecker U, Quail PH (2001). "The phytochrome A-specific signaling intermediate SPA1 interacts directly with COP1, a constitutive repressor of light signaling in Arabidopsis.". J. Biol. Chem. 276 (41): 38173–8. doi:10.1074/jbc.M103140200. PMID 11461903.
- Yi C, Wang H, Wei N, Deng XW (2003). "An initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, COP1". BMC Cell Biol. 3: 30. doi:10.1186/1471-2121-3-30. PMC 138799. PMID 12466024.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Bianchi E, Denti S, Catena R et al. (2003). "Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity". J. Biol. Chem. 278 (22): 19682–90. doi:10.1074/jbc.M212681200. PMID 12615916.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Wertz IE, O'Rourke KM, Zhang Z et al. (2004). "Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase". Science 303 (5662): 1371–4. doi:10.1126/science.1093549. PMID 14739464.
- Dornan D, Wertz I, Shimizu H et al. (2004). "The ubiquitin ligase COP1 is a critical negative regulator of p53". Nature 429 (6987): 86–92. doi:10.1038/nature02514. PMID 15103385.
- Dornan D, Bheddah S, Newton K et al. (2004). "COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas". Cancer Res. 64 (20): 7226–30. doi:10.1158/0008-5472.CAN-04-2601. PMID 15492238.
- Dornan D, Shimizu H, Mah A et al. (2006). "ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage". Science 313 (5790): 1122–6. doi:10.1126/science.1127335. PMID 16931761.
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