RFC1

From Wikipedia, the free encyclopedia
Replication factor C (activator 1) 1, 145kDa

Rendering based on PDB 2EBU.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsRFC1; A1; MHCBFB; PO-GA; RECC1; RFC; RFC140
External IDsOMIM: 102579 MGI: 97891 HomoloGene: 2187 GeneCards: RFC1 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez598119687
EnsemblENSG00000035928ENSMUSG00000029191
UniProtP35251P35601
RefSeq (mRNA)NM_001204747NM_011258
RefSeq (protein)NP_001191676NP_035388
Location (UCSC)Chr 4:
39.29 – 39.37 Mb		Chr 5:
65.26 – 65.34 Mb
PubMed search
This box:

Replication factor C subunit 1 is a protein that in humans is encoded by the RFC1 gene.[1][2]

The protein encoded by this gene is the large subunit of replication factor C, which is a five subunit DNA polymerase accessory protein. Replication factor C is a DNA-dependent ATPase that is required for eukaryotic DNA replication and repair. The protein acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It also may have a role in telomere stability.[2]

Interactions

RFC1 has been shown to interact with BRD4,[3] HDAC1,[4] RFC3,[5][6][7] RELA[8] and PCNA.[3][9][10][11][12]

References

  1. ↑ Luckow B, Bunz F, Stillman B, Lichter P, Schutz G (Mar 1994). "Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans". Mol Cell Biol 14 (3): 1626–34. PMC 358521. PMID 8114700. 
  2. ↑ 2.0 2.1 "Entrez Gene: RFC1 replication factor C (activator 1) 1, 145kDa". 
  3. ↑ 3.0 3.1 Maruyama, Tetsuo; Farina Andrea, Dey Anup, Cheong JaeHun, Bermudez Vladimir P, Tamura Tomohiko, Sciortino Selvaggia, Shuman Jon, Hurwitz Jerard, Ozato Keiko (Sep 2002). "A Mammalian Bromodomain Protein, Brd4, Interacts with Replication Factor C and Inhibits Progression to S Phase". Mol. Cell. Biol. (United States) 22 (18): 6509–20. doi:10.1128/MCB.22.18.6509-6520.2002. ISSN 0270-7306. PMC 135621. PMID 12192049. 
  4. ↑ Anderson, Lisa A; Perkins Neil D (Aug 2002). "The large subunit of replication factor C interacts with the histone deacetylase, HDAC1". J. Biol. Chem. (United States) 277 (33): 29550–4. doi:10.1074/jbc.M200513200. ISSN 0021-9258. PMID 12045192. 
  5. ↑ Ellison, V; Stillman B (Mar 1998). "Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity". J. Biol. Chem. (UNITED STATES) 273 (10): 5979–87. doi:10.1074/jbc.273.10.5979. ISSN 0021-9258. PMID 9488738. 
  6. ↑ Uhlmann, F; Cai J, Flores-Rozas H, Dean F B, Finkelstein J, O'Donnell M, Hurwitz J (Jun 1996). "In vitro reconstitution of human replication factor C from its five subunits". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (13): 6521–6. doi:10.1073/pnas.93.13.6521. ISSN 0027-8424. PMC 39056. PMID 8692848. 
  7. ↑ Tomida, Junya; Masuda Yuji, Hiroaki Hidekazu, Ishikawa Tomoko, Song Ihnyoung, Tsurimoto Toshiki, Tateishi Satoshi, Shiomi Tadahiro, Kamei Yasuhiro, Kim Jinhyeong, Kamiya Kenji, Vaziri Cyrus, Ohmori Haruo, Todo Takeshi (Apr 2008). "DNA Damage-induced Ubiquitylation of RFC2 Subunit of Replication Factor C Complex". J. Biol. Chem. (United States) 283 (14): 9071–9. doi:10.1074/jbc.M709835200. ISSN 0021-9258. PMC 2431014. PMID 18245774. 
  8. ↑ Anderson, Lisa A; Perkins Neil D (Jan 2003). "Regulation of RelA (p65) Function by the Large Subunit of Replication Factor C". Mol. Cell. Biol. (United States) 23 (2): 721–32. doi:10.1128/MCB.23.2.721-732.2003. ISSN 0270-7306. PMC 151544. PMID 12509469. 
  9. ↑ Fotedar, R; Mossi R, Fitzgerald P, Rousselle T, Maga G, Brickner H, Messier H, Kasibhatla S, Hübscher U, Fotedar A (Aug 1996). "A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells". EMBO J. (ENGLAND) 15 (16): 4423–33. ISSN 0261-4189. PMC 452166. PMID 8861969. 
  10. ↑ Mossi, R; Jónsson Z O, Allen B L, Hardin S H, Hübscher U (Jan 1997). "Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen". J. Biol. Chem. (UNITED STATES) 272 (3): 1769–76. doi:10.1074/jbc.272.3.1769. ISSN 0021-9258. PMID 8999859. 
  11. ↑ van der Kuip, H; Carius B, Haque S J, Williams B R, Huber C, Fischer T (Apr 1999). "The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins". J. Mol. Med. (GERMANY) 77 (4): 386–92. doi:10.1007/s001090050365. ISSN 0946-2716. PMID 10353443. 
  12. ↑ Ohta, Satoshi; Shiomi Yasushi, Sugimoto Katsunori, Obuse Chikashi, Tsurimoto Toshiki (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. (United States) 277 (43): 40362–7. doi:10.1074/jbc.M206194200. ISSN 0021-9258. PMID 12171929. 

Further reading


This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.