RENBP
From Wikipedia, the free encyclopedia
| Renin binding protein | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | RENBP; RBP; RNBP | ||||||||||||
| External IDs | OMIM: 312420 MGI: 105940 HomoloGene: 2184 GeneCards: RENBP Gene | ||||||||||||
| EC number | 5.1.3.8 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5973 | 19703 | |||||||||||
| Ensembl | ENSG00000102032 | ENSMUSG00000031387 | |||||||||||
| UniProt | P51606 | P82343 | |||||||||||
| RefSeq (mRNA) | NM_002910 | NM_001164704 | |||||||||||
| RefSeq (protein) | NP_002901 | NP_001158176 | |||||||||||
| Location (UCSC) | Chr HG1497_PATCH: 153.14 – 153.15 Mb | Chr X: 73.92 – 73.93 Mb | |||||||||||
| PubMed search | |||||||||||||
N-acylglucosamine 2-epimerase is an enzyme that in humans is encoded by the RENBP gene.[1][2]
The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature.[2]
References
- ↑ Takahashi S, Inoue H, Miyake Y (Aug 1992). "The human gene for renin-binding protein". J Biol Chem 267 (18): 13007–13. PMID 1618798.
- ↑ 2.0 2.1 "Entrez Gene: RENBP renin binding protein".
Further reading
- Inoue H, Takahashi S, Fukui K, Miyake Y (1992). "Genetic and molecular properties of human and rat renin-binding proteins with reference to the function of the leucine zipper motif". J. Biochem. 110 (4): 493–500. PMID 1723410.
- Takahashi S, Miura R, Miyake Y (1985). "A study on renin binding protein (RnBP) in the human kidney". J. Biochem. 97 (2): 671–7. PMID 3924907.
- Murakami K, Hirose S, Chino S, et al. (1983). "Properties of renin-binding protein". Clinical and experimental hypertension. Part A, Theory and practice 4 (11–12): 2073–81. doi:10.3109/10641968209062372. PMID 6756682.
- Faranda S, Frattini A, Vezzoni P (1995). "The human genes encoding renin-binding protein and host cell factor are closely linked in Xq28 and transcribed in the same direction". Gene 155 (2): 237–9. doi:10.1016/0378-1119(94)00810-F. PMID 7721097.
- van den Ouweland AM, Verdijk M, Kiochis P, et al. (1994). "The human renin-binding protein gene (RENBP) maps in Xq28". Genomics 21 (1): 279–81. doi:10.1006/geno.1994.1259. PMID 8088804.
- Knöll A, Schunkert H, Reichwald K, et al. (1998). "Human renin binding protein: complete genomic sequence and association of an intronic T/C polymorphism with the prorenin level in males". Hum. Mol. Genet. 6 (9): 1527–34. doi:10.1093/hmg/6.9.1527. PMID 9285790.
- Brenner V, Nyakatura G, Rosenthal A, Platzer M (1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.
- Stäsche R, Hinderlich S, Weise C, et al. (1997). "A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase". J. Biol. Chem. 272 (39): 24319–24. doi:10.1074/jbc.272.39.24319. PMID 9305888.
- Takahashi S, Takahashi K, Kaneko T, et al. (1999). "Human renin-binding protein is the enzyme N-acetyl-D-glucosamine 2-epimerase". J. Biochem. 125 (2): 348–53. PMID 9990133.
- Takahashi S, Kumagai M, Shindo S, et al. (2001). "Renin inhibits N-acetyl-D-glucosamine 2-epimerase (renin-binding protein)". J. Biochem. 128 (6): 951–6. PMID 11098137.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Lapteva N, Nieda M, Ando Y, et al. (2001). "Expression of renin-angiotensin system genes in immature and mature dendritic cells identified using human cDNA microarray". Biochem. Biophys. Res. Commun. 285 (4): 1059–65. doi:10.1006/bbrc.2001.5215. PMID 11467860.
- Takahashi S, Ogasawara H, Takahashi K, et al. (2002). "Identification of a domain conferring nucleotide binding to the N-acetyl-d-glucosamine 2-epimerase (Renin binding protein)". J. Biochem. 131 (4): 605–10. PMID 11926999.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Luchansky SJ, Yarema KJ, Takahashi S, Bertozzi CR (2003). "GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism". J. Biol. Chem. 278 (10): 8035–42. doi:10.1074/jbc.M212127200. PMID 12499362.
- Bohlmeyer T, Ferdensi A, Bristow MR, et al. (2003). "Selective activation of N-acyl-D-glucosamine 2-epimerase expression in failing human heart ventricular myocytes". J. Card. Fail. 9 (1): 59–68. doi:10.1054/jcaf.2003.6. PMID 12612874.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
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