RECQL5

From Wikipedia, the free encyclopedia

RecQ protein-like 5

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
4BK0

Identifiers

RECQL5; RECQ5

External IDs

OMIM: 603781 MGI: 2156841 HomoloGene: 31232 GeneCards: RECQL5 Gene

Gene Ontology
Molecular function	• nucleic acid binding • DNA helicase activity • ATP binding • ATP-dependent helicase activity
Cellular component	• nucleus • nucleoplasm • nucleolus • cytoplasm • DNA-directed RNA polymerase II, holoenzyme • nuclear membrane
Biological process	• DNA metabolic process • DNA repair • DNA recombination • DNA duplex unwinding
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000108469

ENSMUSG00000020752

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
73.62 – 73.66 Mb

Chr 11:
115.89 – 115.93 Mb

PubMed search

ATP-dependent DNA helicase Q5 is an enzyme that in humans is encoded by the RECQL5 gene.^[1]^[2]

Interactions

RECQL5 has been shown to interact with EEF1G.^[3]

References

↑ Kitao S, Ohsugi I, Ichikawa K, Goto M, Furuichi Y, Shimamoto A (Feb 1999). "Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes". Genomics 54 (3): 443–52. doi:10.1006/geno.1998.5595. PMID 9878247.
↑ "Entrez Gene: RECQL5 RecQ protein-like 5".
↑ Stelzl, Ulrich; Worm Uwe, Lalowski Maciej, Haenig Christian, Brembeck Felix H, Goehler Heike, Stroedicke Martin, Zenkner Martina, Schoenherr Anke, Koeppen Susanne, Timm Jan, Mintzlaff Sascha, Abraham Claudia, Bock Nicole, Kietzmann Silvia, Goedde Astrid, Toksöz Engin, Droege Anja, Krobitsch Sylvia, Korn Bernhard, Birchmeier Walter, Lehrach Hans, Wanker Erich E (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell (United States) 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. ISSN 0092-8674. PMID 16169070. Cite uses deprecated parameters (help)

Further reading

Sekelsky JJ, Brodsky MH, Rubin GM, Hawley RS (1999). "Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing.". Nucleic Acids Res. 27 (18): 3762–9. doi:10.1093/nar/27.18.3762. PMC 148633. PMID 10471747.
Shimamoto A, Nishikawa K, Kitao S, Furuichi Y (2000). "Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta.". Nucleic Acids Res. 28 (7): 1647–55. doi:10.1093/nar/28.7.1647. PMC 102787. PMID 10710432.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Garcia PL, Liu Y, Jiricny J, et al. (2005). "Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide.". EMBO J. 23 (14): 2882–91. doi:10.1038/sj.emboj.7600301. PMC 514958. PMID 15241474.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Hu Y, Lu X, Barnes E, et al. (2005). "Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers.". Mol Cell Biol. 25 (9): 3431–42. doi:10.1128/MCB.25.9.3431-3442.2005. PMC 1084310. PMID 15831450.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Kanagaraj R, Saydam N, Garcia PL, et al. (2006). "Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork.". Nucleic Acids Res. 34 (18): 5217–31. doi:10.1093/nar/gkl677. PMC 1635296. PMID 17003056.
Hu Y, Raynard S, Sehorn MG, et al. (2007). "RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.". Genes Dev. 21 (23): 3073–84. doi:10.1101/gad.1609107. PMC 2081974. PMID 18003859.

This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.