REC8
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| REC8 homolog (yeast) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | REC8; HR21spB; REC8L1; Rec8p | ||||||||||||
| External IDs | OMIM: 608193 MGI: 1929645 HomoloGene: 3768 GeneCards: REC8 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9985 | 56739 | |||||||||||
| Ensembl | ENSG00000100918 | ENSMUSG00000002324 | |||||||||||
| UniProt | O95072 | Q8C5S7 | |||||||||||
| RefSeq (mRNA) | NM_001048205 | NM_020002 | |||||||||||
| RefSeq (protein) | NP_001041670 | NP_064386 | |||||||||||
| Location (UCSC) | Chr 14: 24.64 – 24.65 Mb | Chr 14: 55.62 – 55.63 Mb | |||||||||||
| PubMed search | |||||||||||||
Meiotic recombination protein REC8 homolog is a protein that in humans is encoded by the REC8 gene.[1][2][3][4]
This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.[4]
Interactions
REC8 has been shown to interact with SMC3.[3]
References
- ↑ Parisi S, McKay MJ, Molnar M, Thompson MA, van der Spek PJ, van Drunen-Schoenmaker E, Kanaar R, Lehmann E, Hoeijmakers JH, Kohli J (May 1999). "Rec8p, a Meiotic Recombination and Sister Chromatid Cohesion Phosphoprotein of the Rad21p Family Conserved from Fission Yeast to Humans". Mol Cell Biol 19 (5): 3515–28. PMC 84144. PMID 10207075.
- ↑ Xu H, Beasley MD, Warren WD, van der Horst GT, McKay MJ (Jun 2005). "Absence of mouse REC8 cohesin promotes synapsis of sister chromatids in meiosis". Dev Cell 8 (6): 949–61. doi:10.1016/j.devcel.2005.03.018. PMID 15935783.
- ↑ 3.0 3.1 Lee J, Iwai T, Yokota T, Yamashita M (May 2003). "Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis". J Cell Sci 116 (Pt 13): 2781–90. doi:10.1242/jcs.00495. PMID 12759374.
- ↑ 4.0 4.1 "Entrez Gene: REC8L1 REC8-like 1 (yeast)".
Further reading
- Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Prieto I, Tease C, Pezzi N et al. (2004). "Cohesin component dynamics during meiotic prophase I in mammalian oocytes". Chromosome Res. 12 (3): 197–213. doi:10.1023/B:CHRO.0000021945.83198.0e. PMID 15125634.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Schleiffer A, Kaitna S, Maurer-Stroh S et al. (2003). "Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners". Mol. Cell 11 (3): 571–5. doi:10.1016/S1097-2765(03)00108-4. PMID 12667442.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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