RBM14

From Wikipedia, the free encyclopedia

RNA binding motif protein 14

PDB rendering based on 2dnp.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2DNP

Identifiers

Symbols

RBM14; COAA; PSP2; SIP; SYTIP1; TMEM137

External IDs

OMIM: 612409 MGI: 1929092 HomoloGene: 4614 GeneCards: RBM14 Gene

Gene Ontology
Molecular function	• nucleotide binding • RNA polymerase II transcription cofactor activity • RNA binding • protein binding • ligand-dependent nuclear receptor transcription coactivator activity • protein binding, bridging
Cellular component	• nucleus • transcription factor complex • nucleolus • mediator complex • ribonucleoprotein complex
Biological process	• DNA replication • DNA repair • DNA recombination • response to hormone stimulus • histone deacetylation • intracellular estrogen receptor signaling pathway • glucocorticoid receptor signaling pathway • positive regulation of transcription from RNA polymerase II promoter
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
66.38 – 66.41 Mb

Chr 19:
4.8 – 4.81 Mb

PubMed search

RNA-binding protein 14 is a protein that in humans is encoded by the RBM14 gene.^[1]^[2]

Interactions

RBM14 has been shown to interact with TARBP2.^[3]

References

↑ Brett D, Whitehouse S, Antonson P, Shipley J, Cooper C, Goodwin G (February 1998). "The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies". Hum Mol Genet 6 (9): 1559–64. doi:10.1093/hmg/6.9.1559. PMID 9285794.
↑ "Entrez Gene: RBM14 RNA binding motif protein 14".
↑ Iwasaki, T; Chin W W, Ko L (September 2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". J. Biol. Chem. (United States) 276 (36): 33375–83. doi:10.1074/jbc.M101517200. ISSN 0021-9258. PMID 11443112. Cite uses deprecated parameters (help)

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Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Iwasaki T, Chin WW, Ko L (2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM).". J. Biol. Chem. 276 (36): 33375–83. doi:10.1074/jbc.M101517200. PMID 11443112.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Perani M, Antonson P, Hamoudi R, et al. (2006). "The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins.". J. Biol. Chem. 280 (52): 42863–76. doi:10.1074/jbc.M502963200. PMID 16227627.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Sui Y, Yang Z, Xiong S, et al. (2007). "Gene amplification and associated loss of 5' regulatory sequences of CoAA in human cancers.". Oncogene 26 (6): 822–35. doi:10.1038/sj.onc.1209847. PMID 16878147.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Yang Z, Sui Y, Xiong S, et al. (2007). "Switched alternative splicing of oncogene CoAA during embryonal carcinoma stem cell differentiation.". Nucleic Acids Res. 35 (6): 1919–32. doi:10.1093/nar/gkl1092. PMC 1874587. PMID 17337438.

PDB gallery

2dnp: Solution structure of RNA binding domain 2 in RNA-binding protein 14

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RBM14

Interactions

References

Further reading