RBCK1

From Wikipedia, the free encyclopedia

RanBP-type and C3HC4-type zinc finger containing 1

PDB rendering based on 2crc.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2CRC, 2LGY, 4DBG

Identifiers

RBCK1; C20orf18; HOIL-1; HOIL1; RBCK2; RNF54; UBCE7IP3; XAP3; XAP4; ZRANB4

External IDs

OMIM: 610924 MGI: 1344372 HomoloGene: 32448 GeneCards: RBCK1 Gene

Gene Ontology
Molecular function	• DNA binding • sequence-specific DNA binding transcription factor activity • ubiquitin-protein ligase activity • protein binding • zinc ion binding • ubiquitin binding
Cellular component	• LUBAC complex
Biological process	• protein polyubiquitination • transcription, DNA-dependent • virus-host interaction • negative regulation of NF-kappaB transcription factor activity • positive regulation of NF-kappaB import into nucleus • positive regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB cascade • proteasomal ubiquitin-dependent protein catabolic process • T cell receptor signaling pathway • positive regulation of NF-kappaB transcription factor activity • protein linear polyubiquitination
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000125826

ENSMUSG00000027466

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 20:
0.39 – 0.41 Mb

Chr 2:
152.32 – 152.33 Mb

PubMed search

RanBP-type and C3HC4-type zinc finger-containing protein 1 is a protein that in humans is encoded by the RBCK1 gene.^[1]

The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms.^[1]

References

↑ 1.0 1.1 "Entrez Gene: RBCK1 RanBP-type and C3HC4-type zinc finger containing 1".

Further reading

Martinez-Noel G, Niedenthal R, Tamura T, Harbers K (1999). "A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4.". FEBS Lett. 454 (3): 257–61. doi:10.1016/S0014-5793(99)00823-6. PMID 10431818.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yamanaka K, Ishikawa H, Megumi Y, et al. (2003). "Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2.". Nat. Cell Biol. 5 (4): 336–40. doi:10.1038/ncb952. PMID 12629548.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Tatematsu K, Yoshimoto N, Koyanagi T, et al. (2005). "Nuclear-cytoplasmic shuttling of a RING-IBR protein RBCK1 and its functional interaction with nuclear body proteins.". J. Biol. Chem. 280 (24): 22937–44. doi:10.1074/jbc.M413476200. PMID 15833741.
Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.". Mol. Cell Proteomics 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
Yoshimoto N, Tatematsu K, Koyanagi T, et al. (2005). "Cytoplasmic tethering of a RING protein RBCK1 by its splice variant lacking the RING domain.". Biochem. Biophys. Res. Commun. 335 (2): 550–7. doi:10.1016/j.bbrc.2005.07.104. PMID 16083853.
Bayle J, Lopez S, Iwaï K, et al. (2006). "The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins.". FEBS Lett. 580 (11): 2609–14. doi:10.1016/j.febslet.2006.03.093. PMID 16643902.
Tian Y, Zhang Y, Zhong B, et al. (2007). "RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation.". J. Biol. Chem. 282 (23): 16776–82. doi:10.1074/jbc.M701913200. PMID 17449468.

PDB gallery

2crc: Solution structure of the zf-RanBP domain of the protein HBV associated factor

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