RAB6B

From Wikipedia, the free encyclopedia

RAB6B, member RAS oncogene family

PDB rendering based on 1yzq.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2E9S, 2FE4, 2FFQ

Identifiers

External IDs

MGI: 107283 HomoloGene: 39749 GeneCards: RAB6B Gene

Gene Ontology
Molecular function	• GTPase activity • GTP binding
Cellular component	• Golgi membrane • Golgi apparatus • cytoplasmic membrane-bounded vesicle
Biological process	• GTP catabolic process • retrograde vesicle-mediated transport, Golgi to ER • small GTPase mediated signal transduction • protein transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000154917

ENSMUSG00000032549

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
133.54 – 133.61 Mb

Chr 9:
103.11 – 103.19 Mb

PubMed search

Ras-related protein Rab-6B is a protein that in humans is encoded by the RAB6B gene.^[1]

References

↑ "Entrez Gene: RAB6B RAB6B, member RAS oncogene family".

Further reading

Chen D, Guo J, Gahl WA (1997). "RAB GTPases expressed in human melanoma cells.". Biochim. Biophys. Acta 1355 (1): 1–6. doi:10.1016/S0167-4889(96)00169-3. PMID 9030196.
Opdam FJ, Echard A, Croes HJ et al. (2000). "The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus". J. Cell. Sci. 113 (15): 2725–35. PMID 10893188.
Monier S, Jollivet F, Janoueix-Lerosey I et al. (2002). "Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport". Traffic 3 (4): 289–97. doi:10.1034/j.1600-0854.2002.030406.x. PMID 11929610.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Garcia-Saez I, Tcherniuk S, Kozielski F (2006). "The structure of human neuronal Rab6B in the active and inactive form". Acta Crystallogr. D Biol. Crystallogr. 62 (Pt 7): 725–33. doi:10.1107/S0907444906015319. PMID 16790928.
Wanschers BF, van de Vorstenbosch R, Schlager MA et al. (2007). "A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells". Exp. Cell Res. 313 (16): 3408–20. doi:10.1016/j.yexcr.2007.05.032. PMID 17707369.

PDB gallery

1yzq: GppNHp-Bound Rab6 GTPase

2fe4: The crystal structure of human neuronal Rab6B in its inactive GDP-bound form

2ffq: The crystal structure of human neuronal Rab6B in its active GTPgS-bound form

2gil: Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8 resolution

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