Quinupristin
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 | |
|---|---|
| Systematic (IUPAC) name | |
| N-{(6R,9S,10R,13S,15aS,18R,22S,24aS)-18-
{[(3S)-1-azabicyclo[2.2.2]oct-3-ylthio]methyl-22-[4-(dimethylamino)benzyl]- 6-ethyl-10,23-dimethyl-5,8,12,15,17,21,24-heptaoxo-13-phenyldocosahydro-12H- pyrido[2,1-f]pyrrolo-[2,1-l][1,4,7,10,13,16] oxapentaazacyclononadecin-9-yl}-3- hydroxypyridine-2-carboxamide | |
| Clinical data | |
| Legal status | ? |
| Pharmacokinetic data | |
| Half-life | 3.1 hours |
| Identifiers | |
| CAS number | 120138-50-3 |
| ATC code | ? |
| PubChem | CID 5388937 |
| ChEMBL | CHEMBL1200649 |
| Chemical data | |
| Formula | C53H67N9O10S |
| Mol. mass | 1022.24 g/mol |
Quinupristin is an antibiotic, often used in combination with dalfopristin under the trade name Synercid. It is active against Gram-positive bacteria, atypical but not Gram negatives. They inhibit protein synthesis of the cells. Quinupristin & dalfopristin are not active against Enterococcus faecalis and they need to be given in combination with other antibacterials for mixed infections which also involve Gram negative organisms.
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