Quaternium-15

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Cis/trans-Quaternium-15
Identifiers
CAS number 4080-31-3 YesY
PubChem 6435993
ChemSpider 23621565 N
UNII E40U03LEM0 YesY
Jmol-3D images {{#if:C1N2CN3CN1C[N+](C2)(C3)CC=CCl.[Cl-]|Image 1
Properties
Molecular formula C9H16Cl2N4
Molar mass 251.16 g mol−1
Hazards
MSDS External MSDS
EU classification Harmful XN; Highly flammable F+
R-phrases R11 R22
S-phrases S16 S36
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Quaternium-15 is a quaternary ammonium salt used as a preservative in many cosmetics and industrial substances. It acts as a formaldehyde releaser. It can cause contact dermatitis, a symptom of an allergic reaction, especially in those with sensitive skin, on an infant's skin, or on sensitive areas such as the genitals.

It can be found under a variety of names, including: Dowicil 75; Dowicil 100; Dowco 184; Dowicide Q; 1-(3-Chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride; N-(3-chloroallyl) hexaminium chloride; hexamethylenetetramine chloroallyl chloride; 3,5,7-triaza-1-azoniaadamantane; 1-(3-chloroallyl)-chloride.

Safety concerns

Quaternium-15 is an allergen, and can cause contact dermatitis in susceptible individuals.[1] Many of those with an allergy to quaternium-15 are also allergic to formaldehyde. Allergic sensitivity to quaternium-15 can be detected using a patch test.[2] It is the single most often found cause of allergic contact dermatitis of the hands (16.5% in 959 cases).[3]

References

  1. ↑ Cahill J, Nixon R. Allergic contact dermatitis to quaternium 15 in a moisturizing lotion. Australasia J Dermatol. 2005 Nov;46(4):284–5. PMID 16197434
  2. ↑ New Zealand Dermatological Society. "Quaternium-15 contact allergy". DermNet NZ. Retrieved 2007-05-31. 
  3. ↑ E. Warshaw, et al. "Contact dermatitis of the hands: Cross-sectional analyses of North American Contact Dermatitis Group Data, 1994–2004". Journal of the American Academy of Dermatology, Volume 57, Issue 2, pp. 301–314

See also

External links

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