Purple glove syndrome

From Wikipedia, the free encyclopedia

Purple Glove Syndrome (PGS) is a poorly understood skin disease in which the extremities become swollen, discoloured and painful.[1] PGS is potentially serious, and may require amputation. PGS is most common among elderly patients and those receiving large, multiple intravenous doses of the epilepsy drug phenytoin.[2]

In November 2010, the FDA's Peripheral and Central Nervous System Drugs Advisory Committee recommended that new warnings be added to phenytoin intravenous (IV) about the risk of purple glove syndrome.[3]

References

  1. ↑ Chokshi R, Openshaw J, Mehta NN, Mohler E (February 2007). "Purple glove syndrome following intravenous phenytoin administration". Vasc Med 12 (1): 29–31. doi:10.1177/1358863X07076551. PMID 17451091. 
  2. ↑ O'Brien TJ, Cascino GD, So EL, Hanna DR (October 1998). "Incidence and clinical consequence of the purple glove syndrome in patients receiving intravenous phenytoin". Neurology 51 (4): 1034–9. PMID 9781525. 
  3. ↑ http://www.aboutlawsuits.com/dilantin-pgs-warning-14041/

External links

  • FDA: Potential Signals of Serious Risks/New Safety Information Identified by the Adverse Event Reporting System (AERS) -- January - March 2008
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