Protopine 6-monooxygenase
| protopine 6-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.55 | ||||||||
| CAS number | 128561-60-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a protopine 6-monooxygenase (EC 1.14.13.55) is an enzyme that catalyzes the chemical reaction
- protopine + NADPH + H+ + O2
6-hydroxyprotopine + NADP+ + H2O
The 4 substrates of this enzyme are protopine, NADPH, H+, and O2, whereas its 3 products are 6-hydroxyprotopine, NADP+, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is protopine,NADPH:oxygen oxidoreductase (6-hydroxylating). This enzyme is also called protopine 6-hydroxylase. This enzyme participates in alkaloid biosynthesis i.
References
- Tanahashi T and Zenk MH (1990). "Elicitor induction and characterization of microsomal protopine-6-hydroxylase, the central enzyme in benzophenanthridine alkaloid biosynthesis". Phytochemistry 29 (4): 1113–1122. doi:10.1016/0031-9422(90)85414-B.