Protopine
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| Protopine[1] | ||
|---|---|---|
 | ||
| IUPAC name 7-Methyl-6,8,9,16-tetrahydrobis[1,3]benzodioxolo[4,5-c:5',6'-g]azecin-15(7H)-one | ||
| Identifiers | ||
| CAS number | 130-86-9  | |
| PubChem | 4970 | |
| ChEMBL | CHEMBL486179  | |
| Jmol-3D images | Image 1 | |
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| Properties | ||
| Molecular formula | C20H19NO5 | |
| Molar mass | 353.369 g/mol | |
| Appearance | white crystals | |
| Density | 1.399 g/cm3 | |
| Melting point | 208 °C | |
| Solubility in water | practically insoluble | |
| Solubility in chloroform | 1:15 | |
| (verify) (what is: /?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | ||
| Infobox references | ||
Protopine is a benzylisoquinoline alkaloid occurring in opium poppy,[2] Corydalis tubers[3] and other plants of the family papaveraceae, like Fumaria officinalis.[4] It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.[5][6]
See also
References
- ↑ The Merck Index (9 ed.). New Jersey: Merck & Co. 1976. p. 1023.
- ↑ The Free Dictionary: Protopine
- ↑ Jiang, B; Cao, K; Wang, R (2004). "Inhibitory effect of protopine on K(ATP) channel subunits expressed in HEK-293 cells.". European Journal of Pharmacology 506 (2): 93–100. doi:10.1016/j.ejphar.2004.11.004. PMID 15588728.
- ↑ Vrba, J.; Vrublova, E.; Modriansky, M.; Ulrichova, J. (2011). "Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR". Toxicology Letters 203 (2): 135–141. doi:10.1016/j.toxlet.2011.03.015. PMID 21419197.
- ↑ Saeed, SA; Gilani, AH; Majoo, RU; Shah, BH (1997). "Anti-thrombotic and anti-inflammatory activities of protopine.". Pharmacological research : the official journal of the Italian Pharmacological Society 36 (1): 1–7. doi:10.1006/phrs.1997.0195. PMID 9368908.
- ↑ Protopine at the US National Library of Medicine Medical Subject Headings (MeSH)
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