Proflavine

Proflavine
IUPAC name acridine-3,6-diamine
Identifiers
CAS number	92-62-6 Y
PubChem	7099
ChemSpider	6832 Y
UNII	CY3RNB3K4T Y
DrugBank	DB01123
KEGG	C11181 Y
ChEBI	CHEBI:8452 Y
ChEMBL	CHEMBL55400 Y
Jmol-3D images	Image 1
SMILES n1c3c(cc2c1cc(N)cc2)ccc(c3)N
InChI InChI=1S/C13H11N3/c14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10/h1-7H,14-15H2 Y Key: WDVSHHCDHLJJJR-UHFFFAOYSA-N Y InChI=1/C13H11N3/c14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10/h1-7H,14-15H2 Key: WDVSHHCDHLJJJR-UHFFFAOYAC
Properties
Molecular formula	C13H11N3
Molar mass	209.25 g mol−1
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Proflavine (pron. pro-fla¢vin), also called proflavin and diaminoacridine, is an acriflavine derivative, a disinfectant bacteriostatic against many gram-positive bacteria. It has been used in the form of the dihydrochloride and hemisulfate salts as a topical antiseptic, and was formerly used as a urinary antiseptic.

Proflavine is also known to have a mutagenic effect on DNA by intercalating between nucleic acid base pairs. It differs from most other mutagenic components by causing basepair-deletions or basepair-insertions and not substitutions.

Proflavine absorbs strongly in the blue region at 445 nm (in water at pH 7) with molar extinction coefficient of c. 40,000^[1]

References