Ponezumab

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Ponezumab ^?
Monoclonal antibody
Type	Whole antibody
Source	Humanized (from mouse)
Target	beta-amyloid
Clinical data
Legal status	?
Identifiers
CAS number	1178862-65-1^N
ATC code	None
UNII	1TG15H1XE9^Y
Chemical data
Formula	C₆₅₅₂H₁₀₁₅₈N₁₇₃₀O₂₀₉₀S₅₂
Mol. mass	148.3 kDa
N (what is this?) (verify)

Ponezumab is a humanized monoclonal antibody designed for the treatment of Alzheimer's disease.^[1]

Ponezumab was developed by Pfizer Inc. In November 2011 Pfizer halted the development of ponezumab after finishing a phase 2 trial.^[2] Detailed reports have to be released.

References

Monoclonals for bone, musculoskeletal, circulatory, and neurologic systems

Bone ("-os-", "-s(o)-")

Human ("-osu-")	Denosumab

Humanized ("-sozu-")	Blosozumab Romosozumab

Musculoskeletal ("-mul-")

Human ("-mulu-")	Stamulumab^†

Circulatory ("-c(i[r])-")

Human ("-ciru-")	Alirocumab Enoticumab Evolocumab Icrucumab Inclacumab Nesvacumab Orticumab Ramucirumab Vesencumab

Mouse ("-ciro-")	Biciromab^‡ Imciromab^‡

Chimeric ("-cixi-")	Abciximab Volociximab

Humanized ("-cizu-")	Alacizumab pegol Bevacizumab/Ranibizumab Caplacizumab Demcizumab Etaracizumab Tadocizumab

Neurologic ("-ne(u)(r)-")

Human ("-neru-")	Aducanumab Atinumab Fasinumab Fulranumab Gantenerumab

Humanized ("-nezu-"/"-neuzu-")	Bapineuzumab^† Crenezumab Ozanezumab Ponezumab Solanezumab Tanezumab

Angiogenesis inhibitor ("-anibi-")

Humanized ("-anibizu-")	Ranibizumab

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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