Polidocanol
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|---|---|
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | Topical: allowed Injection: contraindication in months 1–3 and after week 36 |
| Legal status | OTC (topical), ℞ (injection) |
| Identifiers | |
| CAS number | 9002-92-0  3055-99-0 (with nine ethyleneglycol units) |
| ATC code | C05BB02 |
| PubChem | CID 656641 |
| UNII | 0AWH8BFG9A  |
| KEGG | D01993 |
| ChEMBL | CHEMBL1201751 |
| Synonyms |
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| Chemical data | |
| Formula | C30H62O10 |
| Mol. mass | ~600 g/mol (average) |
| (what is this?) (verify) | |
Polidocanol is a local anaesthetic and antipruritic component of ointments and bath additives. It relieves itching caused for example by dry skin conditions such as eczema.[1]
The substance is also used as a sclerosant, an irritant injected to treat varicose veins, under the trade names Asclera and Aethoxysklerol.[2] Polidocanol causes fibrosis inside varicose veins, occluding the lumen of the vessel, and reducing the appearance of the varicosity.
The FDA has approved polidocanol injections for the treatment of small varicose (less than 1 mm in diameter) and reticular veins (1 to 3 mm in diameter). Polidocanol works by damaging the cell lining of blood vessels, causing them to close and eventually be replaced by other types of tissue.[3][4]
References
- ↑ "E45 itch relief cream". netdoctor.co.uk. Retrieved 2007-07-12.
- ↑ Sclerotherapy, Laurence Z Rosenberg, MD, eMedicine.com
- ↑ Facts and Companies: Varicose Vein Treatment Approved
- ↑ "Asclera Full Prescribing Information in Drug Reference Encyclopedia". Retrieved 2010-04-11.
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