Piperaquine

From Wikipedia, the free encyclopedia
Piperaquine
Systematic (IUPAC) name
1,3-bis[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propane
Clinical data
Legal status ?
Identifiers
CAS number 4085-31-8 YesY
ATC code ?
PubChem CID 122262
UNII A0HV2Q956Y N
ChEMBL CHEMBL303933 N
Chemical data
Formula C29H32Cl2N6 
Mol. mass 535.51
 N (what is this?)  (verify)

Piperaquine is an antimalarial drug, a bisquinoline first synthesised in the 1960s, and used extensively in China and Indochina as prophylaxis and treatment during the next 20 years. Usage declined in the 1980s as piperaquine-resistant strains of P. falciparum arose and artemisinin-based antimalarials became available. However, Chinese scientists have been studying whether piperaquine can still be used therapeutically in combination with artemisinin.[1]

Piperaquine is characterized by slow absorption and a long biological half-life,[2] making it a good partner drug with artemisinin derivatives which are fast acting but have a short biological half-life.[3]

The fixed-dose combination dihydroartemisinin-piperaquine (Eurartesim) was submitted for approval to the European Medicines Agency in 2009.[4]

References

  1. ↑ Davis TM, Hung TY, Sim IK, Karunajeewa HA, Ilett KF (2005). "Piperaquine: a resurgent antimalarial drug". Drugs 65 (1): 75–87. PMID 15610051. 
  2. ↑ D'alessandro U. (2009). "Progress in the development of piperaquine combinations for the treatment of malaria". Curr Opin Infect Dis 22 (6): 588–92. doi:10.1097/QCO.0b013e328332674a. PMID 19773652. 
  3. ↑ http://apps.who.int/prequal/info_applicants/Guidelines/Nonclinical_Overview_Artemisinin-Derivatives.pdf"
  4. ↑ Medicines for Malaria. "Registration". Retrieved 2010-06-20. 



This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.