Piers Nash

From Wikipedia, the free encyclopedia
Professor
Piers David Nash
Born (1969-08-08) August 8, 1969
Exeter, England
Nationality  United Kingdom
 Canada
 United States
Fields Biochemistry, Cell Biology
Institutions University of Chicago
Alma mater University of Alberta
University of Guelph
Booth School of Business
Doctoral advisor Grant McFadden
Doctoral students Bernard Liu, Ilana Berlin, Maria Sierra, Brett Engelmann
Known for Cellular signal transduction
Influences Anthony Pawson

Piers David Nash (born August 8, 1969) is the Senior Director of Campaign Planning for Academic Research at the University of Chicago Medicine and Biological Sciences Division. He is the son of Roger Nash and Chris Nash (Bronwen Christine Harrhy), and brother of Caedmon Nash. He is a resident of Chicago where he lives with his wife, Elke Aippersbach, and their son, Jasper Nash.

Born in Exeter, England, and grew up in Sudbury, Canada. He received a B.Sc. with Honours, in Biochemistry from the University of Guelph and the Chemical Institute of Canada prize for the top of class. He received a Ph.D in 1999 from the University of Alberta working in the laboratory of Dr. Grant McFadden investigating poxviral immunomodulatory proteins. His doctoral thesis focused on the enzymology and biological properties of the Myxoma virus encoded serine proteinase inhibitor (serpin), SERP-1. He completed postdoctoral research with Dr. Tony Pawson at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital and the University of Toronto from June 1999 to December 2003. He was a Professor in The Ben May Department for Cancer Research and a Scientist of the Comprehensive Cancer Center at The University of Chicago from 2004-2012 and a Fellow of the Institute for Genomics and Systems Biology [1] from 2006-2012. As a scientist he investigates protein-protein interactions involved in signal transduction, and the molecular mechanisms by which cells respond to external cues. His work at The University of Chicago focused on understanding the SH2 domain at a systems level and investigating the role of ubiquitination in controlling endocytosis and modulating signal transduction. Earlier work focused on emergent properties of complex systems such as ultrasensitivity (all-or-none switches) at critical junctures in the cell cycle.

ResearchGate reports 46 peer-reviewed published works in a wide range of fields, including signal transduction, cell biology, molecular evolution, cell cycle, cognition and memory, meteorology, and pedagogy.[2] Scopus notes an h-index of 22 and 3262 citations [3] on 44 publications tracked in that database.

Publications

Research Papers

  • Nash, P. (1984). "Differential Effects of Wind Speed on Low Temperature Evaporation". Chinook 6: 92–3. 
  • Nash, C. H.; Nash, P. (1986). "Correlates of Colour Memory: A Neglected Field of Research". Future Health 8: 15–6. 
  • Nash, Piers D.; Davison, Laura (Winter 1989). "What Gifted Secondary School Students Tell about Their School Programs". Canadian Journal of Education 14 (1): 109–18. doi:10.2307/1495206. JSTOR 1495206. 
  • Maksymowych, WP; Nation, N; Nash, P; Macen, J; Lucas, A; McFadden, G; Russell, AS (1996). "Amelioration of antigen induced arthritis in rabbits treated with a secreted viral serine proteinase inhibitor". The Journal of rheumatology 23 (5): 878–82. PMID 8724302. 
  • Lucas, A.; Liu, L.-y.; Macen, J.; Nash, P.; Dai, E.; Stewart, M.; Graham, K.; Etches, W. et al. (1996). "Virus-Encoded Serine Proteinase Inhibitor SERP-1 Inhibits Atherosclerotic Plaque Development After Balloon Angioplasty". Circulation 94 (11): 2890–900. doi:10.1161/01.CIR.94.11.2890. PMID 8941118. 
  • Nash, P.; Whitty, A; Handwerker, J; Macen, J; McFadden, G (1998). "Inhibitory Specificity of the Anti-inflammatory Myxoma Virus Serpin, SERP-1". Journal of Biological Chemistry 273 (33): 20982–91. doi:10.1074/jbc.273.33.20982. PMID 9694848. 
  • Christov, Alexander; Dai, Erbin; Liu, Liying; Miller, Leslie W.; Nash, Piers; Lalani, Alshad; McFadden, Grant; Nation, Patric N. et al. (1999). "Detection of transplant vasculopathy in a rat aortic allograft model by fluorescence spectroscopic optical analysis". Lasers in Surgery and Medicine 24 (5): 346–59. doi:10.1002/(SICI)1096-9101(1999)24:5<346::AID-LSM5>3.0.CO;2-K. PMID 10406475. 
  • Miller, L. W.; Dai, E.; Nash, P.; Liu, L.; Icton, C.; Klironomos, D.; Fan, L.; Nation, P. N. et al. (2000). "Inhibition of Transplant Vasculopathy in a Rat Aortic Allograft Model After Infusion of Anti-Inflammatory Viral Serpin". Circulation 101 (13): 1598–605. doi:10.1161/01.CIR.101.13.1598. PMID 10747355. 
  • Lucas, A; Dai, E; Liu, L; Guan, H; Nash, P; McFadden, G; Miller, L (2000). "Transplant vasculopathy: Viral anti-inflammatory serpin regulation of atherogenesis". The Journal of Heart and Lung Transplantation 19 (11): 1029–38. doi:10.1016/S1053-2498(00)00190-X. PMID 11077219. 
  • Nash, P; Barry, M; Seet, BT; Veugelers, K; Hota, S; Heger, J; Hodgkinson, C; Graham, K et al. (2000). "Post-translational modification of the myxoma-virus anti-inflammatory serpin SERP-1 by a virally encoded sialyltransferase". The Biochemical journal 347 (Pt 2): 375–82. doi:10.1042/0264-6021:3470375. PMC 1220969. PMID 10749666. 
  • Christov, Alexander; Dai, Erbin; Drangova, Maria; Liu, Liying; Abela, George S.; Nash, Piers; McFadden, Grant; Lucas, Alexandra (2007). "Optical Detection of Triggered Atherosclerotic Plaque Disruption by Fluorescence Emission Analysis". Photochemistry and Photobiology 72 (2): 242–52. doi:10.1562/0031-8655(2000)0720242ODOTAP2.0.CO2. PMID 10946579. 
  • Nash, Piers; McFadden, Grant; Whitty, Adrian (2000). "Application of linear free energy relationships to the serpin–proteinase inhibition mechanism". FEBS Letters 475 (1): 1–6. doi:10.1016/S0014-5793(00)01620-3. PMID 10854846. 
  • Nash, Piers; Tang, Xiaojing; Orlicky, Stephen; Chen, Qinghua; Gertler, Frank B.; Mendenhall, Michael D.; Sicheri, Frank; Pawson, Tony et al. (2001). "Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication". Nature 414 (6863): 514–21. doi:10.1038/35107009. PMID 11734846. 
This article was the focus of the following reviews and comments:
Ferrell, James E. (2001). "Cell cycleSix steps to destruction". Nature 414 (6863): 498–9. doi:10.1038/35107180. PMID 11734834. 
Deshaies, Raymond J.; Ferrell Jr., James E. (2001). "Multisite Phosphorylation and the Countdown to S Phase". Cell 107 (7): 819–22. doi:10.1016/S0092-8674(01)00620-1. PMID 11779457. 
Harper, J.Wade (2002). "A phosphorylation-driven ubiquitination switch for cell-cycle control". Trends in Cell Biology 12 (3): 104–7. doi:10.1016/S0962-8924(01)02238-3. PMID 11859016. 
Tromans, Amanda (2001). "Switching on S phase". Nature Reviews Molecular Cell Biology 2 (12): 873. doi:10.1038/35103051. PMID 11733763. 
Adler, E. M.; Gough, N. R.; Ray, L. B. (2005). "2004: Signaling Breakthroughs of the Year". Science Signaling 2005 (265): eg1. doi:10.1126/stke.2652005eg1. 

Book Chapters

  • Nash, Piers; Lucas, Alexandra; McFadden, Grant (1997). "Serp-1, A Poxvirus-Encoded Serpin, Is Expressed as a Secreted Glycoprotein that Inhibits the Inflammatory Response to Myxoma Virus Infection". In Church, Frank C.; Cunningham, Dennis D.; Ginsburg, David; Hoffman, Maureane; Stone, Stuart R.; Tollefsen, Douglas M. Chemistry and Biology of Serpins. Advances in Experimental Medicine and Biology 425. pp. 195–205. doi:10.1007/978-1-4615-5391-5_19. ISBN 978-1-4613-7461-9. 
  • Lalani, A.; Nash, P.; Seet, B.; Robichaud, J.; McFadden, G. (1999). "Interaction of DNA virus proteins with host cytokines". In Cann, A. DNA Viruses: A Practical Approach. Practical Approach Series. Oxford University Press. pp. 177–208. 
  • Zalai, Christian V.; Nash, Piers; Dai, Erbin; Liu, Li Ying; Lucas, Alexandra (2002). "The Potential Role of Serine Proteinase Inhibitors for the Prevention of Plaque Rupture". In Brown, David L. Cardiovascular Plaque Rupture. CRC Press. pp. 447–82. ISBN 978-0-8247-0276-2. 
  • Pawson, T.; Nash, P. (2003). "Modular protein interaction domains in cellular communication". Handbook of Cell Signaling 1. pp. 379–85. 
  • Pawson, Tony; Gish, Gerald D.; Nash, Piers (2006). "The SH2 Domain: a Prototype for Protein Interaction Modules". In Cesareni, Giovanni; Gimona, Mario; Sudol, Marius et al. Modular Protein Domains. Wiley. pp. 5–36. ISBN 978-3-527-60589-7. 
  • Pawson, Tony; Nash, Piers (2011). "Modular Protein Interaction Domains in Cellular Communication". In Dennis, Edward A.; Bradshaw, Ralph A. Transduction Mechanisms in Cellular Signaling: Cell Signaling Collection. Academic Press. pp. 19–31. ISBN 978-0-12-383863-6. 

Review Articles

  • Nash, Piers D.; Opas, Michal; Michalak, Marek (1994). "Calreticulin: Not just another calcium-binding protein". Molecular and Cellular Biochemistry 135 (1): 71–8. doi:10.1007/BF00925962. PMID 7816058. 
  • McFadden, G; Graham, K; Ellison, K; Barry, M; Macen, J; Schreiber, M; Mossman, K; Nash, P et al. (1995). "Interruption of cytokine networks by poxviruses: Lessons from myxoma virus". Journal of leukocyte biology 57 (5): 731–8. PMID 7759953. 
  • McFadden, G.; Lalani, A.; Everett, H.; Nash, P.; Xu, X. (1998). "Virus-encoded receptors for cytokines and chemokines". Seminars in Cell & Developmental Biology 9 (3): 359. doi:10.1006/scdb.1998.0245. 
  • Nash, Piers; Barrett, John; Cao, Jing-Xin; Hota-Mitchell, Sheela; Lalani, Alshad S.; Everett, Helen; Xu, Xiao-Ming; Robichaud, Janine et al. (1999). "Immunomodulation by viruses: The myxoma virus story". Immunological Reviews 168: 103–20. doi:10.1111/j.1600-065X.1999.tb01286.x. PMID 10399068. 
  • Upton, C.; Macen, J.L.; Schreiber, M.; McFaddeni, G. (1991). "Myxoma virus expresses a secreted protein with homology to the tumor necrosis factor receptor gene family that contributes to viral virulence". Virology 184 (1): 370–82. doi:10.1016/0042-6822(91)90853-4. PMID 1651597. 
  • Pawson, Tony; Nash, Piers (2000). "Protein–protein interactions define specificity in signal transduction". Genes & Development 14 (9): 1027–47. doi:10.1101/gad.14.9.1027 (inactive July 23, 2013). PMID 10809663. 
  • Pawson, Tony; Gish, Gerald D; Nash, Piers (2001). "SH2 domains, interaction modules and cellular wiring". Trends in Cell Biology 11 (12): 504–11. doi:10.1016/S0962-8924(01)02154-7. PMID 11719057. 
  • Pawson, Tony; Raina, Monica; Nash, Piers (2002). "Interaction domains: From simple binding events to complex cellular behavior". FEBS Letters 513 (1): 2–10. doi:10.1016/S0014-5793(01)03292-6. PMID 11911873. 
  • Pawson, T.; Nash, P (2003). "Assembly of Cell Regulatory Systems Through Protein Interaction Domains". Science 300 (5618): 445–52. doi:10.1126/science.1083653. PMID 12702867. 
This was the focus of the following review:
Gough, N. R.; Adler, E. M.; Ray, L. B. (2003). "Focus Issue: Cellular Regulation Through Protein Interaction Domains". Science Signaling 2003 (179): eg6. doi:10.1126/scisignal.1792003eg6. 

Honors and awards

Paul Harris Fellow of Rotary International
1987 President's Scholar, University of Guelph top entrance award
1992-1994 NSERC Graduate Fellowship
1992-1994 University of Alberta Walter Johns Award
1992-1997 AHFMR Graduate Fellowship
1996-1997 University of Alberta Walter Johns Award
1997-1998 University of Alberta Dissertation Scholarship
1999 NSERC Postdoctoral Fellowship (declined)
1999-2002 MRC/CIHR Postdoctoral Fellowship Award
2002 NCIC Postdoctoral Fellowship (declined)
2002-2004 CIHR Senior Research Fellowship
2005 Cancer Research Foundation Young Investigator Award
2005-2006 Leukemia Research Foundation New Investigator Award
2006-2008 Jimmy V Foundation Scholar

Notes

  1. ↑ http://www.igsb.org Institute for Genomics and Systems Biology
  2. ↑ ResearchGate Profile of Piers Nash Feb 5, 2013 (see External Links)
  3. ↑ Scopus profile of Piers D. Nash Jan 22, 2014 (see External Links)

External links

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