Phosphatidylethanolamine N-methyltransferase

Thus, the two substrates of this enzyme are S-adenosyl methionine and phosphatidylethanolamine, whereas its two products are S-adenosylhomocysteine and phosphatidyl-N-methylethanolamine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase. Other names in common use include PEMT, LMTase, lipid methyl transferase, phosphatidylethanolamine methyltransferase, phosphatidylethanolamine-N-methylase, and phosphatidylethanolamine-S-adenosylmethionine methyltransferase. This enzyme participates in glycine, serine and threonine metabolism and glycerophospholipid metabolism.

References

Hirata F, Viveros OH, Diliberto EJ Jr, Axelrod J (1978). "Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine". Proc. Natl. Acad. Sci. U.S.A. 75 (4): 1718–21. doi:10.1073/pnas.75.4.1718. PMC 392410. PMID 25437.
Morgan TE (1969). "Isolation and characterization of lipid N-methylrtansferase from dog lung". Biochim. Biophys. Acta. 178 (1): 21–34. PMID 5773456.
Schneider WJ, Vance DE (1979). "Conversion of phosphatidylethanolamine to phosphatidylcholine in rat liver. Partial purification and characterization of the enzymatic activities". J. Biol. Chem. 254 (10): 3886–91. PMID 438165.

Transferase: one carbon transferases (EC 2.1)

2.1.1: Methyl-

N-	Histamine N-methyltransferase Phenylethanolamine N-methyltransferase Amine N-methyltransferase Phosphatidylethanolamine N-methyltransferase

O-	5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase Catechol-O-methyl transferase

Homocysteine	Betaine-homocysteine methyltransferase Homocysteine methyltransferase Methionine synthase

Other	Phosphatidyl ethanolamine methyltransferase DNMT3B Histone methyltransferase Thymidylate synthase DNA methyltransferase Thiopurine methyltransferase

2.1.2: Hydroxymethyl-,
Formyl- and Related

Hydroxymethyltransferase	Serine hydroxymethyltransferase 3-methyl-2-oxobutanoate hydroxymethyltransferase

Formyltransferase	Phosphoribosylglycinamide formyltransferase Inosine monophosphate synthase

Other	Glutamate formimidoyltransferase Aminomethyltransferase

2.1.3: Carboxy- and Carbamoyl

Carboxy	methylmalonyl-CoA carboxytransferase

Carbamoyl	Aspartate carbamoyltransferase Ornithine carbamoyltransferase Oxamate carbamoyltransferase Putrescine carbamoyltransferase 3-hydroxymethylcephem carbamoyltransferase Lysine carbamoyltransferase N-acetylornithine carbamoyltransferase

2.1.4: Amidino

Arginine:glycine amidinotransferase

B
enzm
1.1
- 2
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- 7
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- 15-18
2.1
- 2
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- 4
- 5
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  - 2.7.10
  - 11-12
- 8
3.1
- - 3.1.3.48
- 2
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- 4
  - 3.4.21
  - 22
  - 23
  - 24
- 5
- 6
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4.1
- 2
- 3
- 4
- 5
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5.1
- 2
- 3
- 4
- 99
6.1-3
- 4
- 5-6

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Phosphatidylethanolamine N-methyltransferase

See also

References