Phenylethanolamine N-methyltransferase

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phenylethanolamine N-methyltransferase
Identifiers
Symbol PNMT
Alt. symbols PENT
Entrez 5409
HUGO 9160
OMIM 171190
RefSeq NM_002686
UniProt P11086
Other data
Locus Chr. 17 q21-q22

Phenylethanolamine N-methyltransferase (PNMT) is an enzyme found in the adrenal medulla that converts norepinephrine (noradrenaline) to epinephrine (adrenaline).

PNMT is positively influenced by cortisol, which is produced in the adrenal cortex.

S-adenosyl-L-methionine (SAM) is a required cofactor.[1] PNMT catalyzes the transfer of a methyl group from SAM to norepinephrine, converting it into epinephrine. This enzyme also converts phenethylamine to N-methylphenethylamine, an isomer of amphetamine.[2][3]

PNMT plays an important role in trace amine and catecholamine biosynthesis.


References

  1. ↑ Wong DL, Lesage A, Siddall B, Funder JW (November 1992). "Glucocorticoid regulation of phenylethanolamine N-methyltransferase in vivo". The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 6 (14): 3310–5. PMID 1426768. 
  2. ↑ Pendleton, RG; Gessner, G; Sawyer, J (September 1980). "Studies on lung N-methyltransferases, a pharmacological approach.". Naunyn-Schmiedeberg's archives of pharmacology 313 (3): 263–8. PMID 7432557. 
  3. ↑ Broadley, KJ (March 2010). "The vascular effects of trace amines and amphetamines.". Pharmacology & therapeutics 125 (3): 363–75. PMID 19948186. 

External links

Transferase: one carbon transferases (EC 2.1)
2.1.1: Methyl-
N-
O-
Homocysteine
Other
2.1.2: Hydroxymethyl-,
Formyl- and Related
Hydroxymethyltransferase
Formyltransferase
Other
2.1.3: Carboxy- and Carbamoyl
Carboxy
Carbamoyl
2.1.4: Amidino
  • Arginine:glycine amidinotransferase
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monoamine
histidine → histamine
anabolism:
catabolism:
tyrosine→dopamine→epinephrine
anabolism:
catabolism:
glutamate→GABA
anabolism:
catabolism:
tryptophan→serotonin→melatonin
arginine→NO
choline→Acetylcholine
anabolism:
catabolism:

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

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