Pesticide

Pesticides are substances meant for attracting, seducing, destroying or mitigating any pest.^[1] They are a class of biocide. The most common use of pesticides is as plant protection products (also known as crop protection products), which in general protect plants from damaging influences such as weeds, plant diseases or insects. This use of pesticides is so common that the term pesticide is often treated as synonymous with plant protection product, although it is in fact a broader term, as pesticides are also used for non-agricultural purposes. The term pesticide includes all of the following: herbicide, insecticide, insect growth regulator, nematicide, termiticide, molluscicide, piscicide, avicide, rodenticide, predacide, bactericide, insect repellent, animal repellent, antimicrobial, fungicide, disinfectant (antimicrobial), and sanitizer.^[2]

In general, a pesticide is a chemical or biological agent (such as a virus, bacterium, antimicrobial, or disinfectant) that deters, incapacitates, kills, or otherwise discourages pests. Target pests can include insects, plant pathogens, weeds, mollusks, birds, mammals, fish, nematodes (roundworms), and microbes that destroy property, cause nuisance, or spread disease, or are disease vectors. Although pesticides have benefits, some also have drawbacks, such as potential toxicity to humans and other desired species. According to the Stockholm Convention on Persistent Organic Pollutants, 9 of the 12 most dangerous and persistent organic chemicals are pesticides.^[3][4]

Definition

The Food and Agriculture Organization (FAO) has defined pesticide as:

any substance or mixture of substances intended for preventing, destroying, or controlling any pest, including vectors of human or animal disease, unwanted species of plants or animals, causing harm during or otherwise interfering with the production, processing, storage, transport, or marketing of food, agricultural commodities, wood and wood products or animal feedstuffs, or substances that may be administered to animals for the control of insects, arachnids, or other pests in or on their bodies. The term includes substances intended for use as a plant growth regulator, defoliant, desiccant, or agent for thinning fruit or preventing the premature fall of fruit. Also used as substances applied to crops either before or after harvest to protect the commodity from deterioration during storage and transport.^[5]

Type of pesticide	Target pest group
Herbicides	Plants
Algicides or Algaecides	Algae
Avicides	Birds
Bactericides	Bacteria
Fungicides	Fungi and Oomycetes
Insecticides	Insects
Miticides or Acaricides	Mites
Molluscicides	Snails
Nematicides	Nematodes
Rodenticides	Rodents
Virucides	Viruses

Pesticides can be classified by target organism (e.g., herbicides, insecticides, fungicides, rodenticides, and pediculicides^[4][6] - see table), chemical structure (e.g., organic, inorganic, synthetic, or biological (biopesticide),^[7] although the distinction can sometimes blur), and physical state (e.g. gaseous (fumigant)).^[7] Biopesticides include microbial pesticides and biochemical pesticides.^[8] Plant-derived pesticides, or "botanicals", have been developing quickly. These include the pyrethroids, rotenoids, nicotinoids, and a fourth group that includes strychnine and scilliroside.^[9]:15

Many pesticides can be grouped into chemical families. Prominent insecticide families include organochlorines, organophosphates, and carbamates. Organochlorine hydrocarbons (e.g., DDT) could be separated into dichlorodiphenylethanes, cyclodiene compounds, and other related compounds. They operate by disrupting the sodium/potassium balance of the nerve fiber, forcing the nerve to transmit continuously. Their toxicities vary greatly, but they have been phased out because of their persistence and potential to bioaccumulate.^{[9]:239–240} Organophosphate and carbamates largely replaced organochlorines. Both operate through inhibiting the enzyme acetylcholinesterase, allowing acetylcholine to transfer nerve impulses indefinitely and causing a variety of symptoms such as weakness or paralysis. Organophosphates are quite toxic to vertebrates, and have in some cases been replaced by less toxic carbamates.^{[9]:136–137} Thiocarbamate and dithiocarbamates are subclasses of carbamates. Prominent families of herbicides include phenoxy and benzoic acid herbicides (e.g. 2,4-D), triazines (e.g., atrazine), ureas (e.g., diuron), and Chloroacetanilides (e.g., alachlor). Phenoxy compounds tend to selectively kill broad-leaf weeds rather than grasses. The phenoxy and benzoic acid herbicides function similar to plant growth hormones, and grow cells without normal cell division, crushing the plant's nutrient transport system.^[9]:300 Triazines interfere with photosynthesis.^[9]:335 Many commonly used pesticides are not included in these families, including glyphosate.

Pesticides can be classified based upon their biological mechanism function or application method. Most pesticides work by poisoning pests.^[10] A systemic pesticide moves inside a plant following absorption by the plant. With insecticides and most fungicides, this movement is usually upward (through the xylem) and outward. Increased efficiency may be a result. Systemic insecticides, which poison pollen and nectar in the flowers, may kill bees and other needed pollinators.

In 2009, the development of a new class of fungicides called paldoxins was announced. These work by taking advantage of natural defense chemicals released by plants called phytoalexins, which fungi then detoxify using enzymes. The paldoxins inhibit the fungi's detoxification enzymes. They are believed to be safer and greener.^[11]

Types

Pesticides are often referred to according to the type of pest they control. Pesticides can also be considered as either biodegradable pesticides, which will be broken down by microbes and other living beings into harmless compounds, or persistent pesticides, which may take months or years before they are broken down: it was the persistence of DDT, for example, which led to its accumulation in the food chain and its killing of birds of prey at the top of the food chain. Another way to think about pesticides is to consider those that are chemical pesticides or are derived from a common source or production method.^[12]

Some examples of chemically-related pesticides are:

Organophosphate pesticides

Organophosphates affect the nervous system by disrupting the enzyme that regulates acetylcholine, a neurotransmitter. Most organophosphates are insecticides. They were developed during the early 19th century, but their effects on insects, which are similar to their effects on humans, were discovered in 1932. Some are very poisonous (they were used in World War II as nerve agents). However, they usually are not persistent in the environment.

Carbamate pesticides

Carbamate pesticides affect the nervous system by disrupting an enzyme that regulates acetylcholine, a neurotransmitter. The enzyme effects are usually reversible. There are several subgroups within the carbamates.

Organochlorine insecticides

They were commonly used in the past, but many have been removed from the market due to their health and environmental effects and their persistence (e.g., DDT and chlordane).

Pyrethroid pesticides

They were developed as a synthetic version of the naturally occurring pesticide pyrethrin, which is found in chrysanthemums. They have been modified to increase their stability in the environment. Some synthetic pyrethroids are toxic to the nervous system.

Sulfonylurea herbicides

Includes nicosulfuron,^[13] triflusulfuron methyl,^[14] and chlorsulfuron broad-spectrum herbicides that kill plants by inhibiting the enzyme acetolactate synthase. In the 1960s, more than 1 kg/ha (0.89 lb/acre) crop protection chemical was typically applied, while sulfonylureates allow as little as 1% as much material to achieve the same effect.^[15]

Biopesticides

Biopesticides are certain types of pesticides derived from such natural materials as animals, plants, bacteria, and certain minerals. For example, canola oil and baking soda have pesticidal applications and are considered biopesticides. At the end of 2001, there were approximately 195 registered biopesticide active ingredients and 780 products. Biopesticides fall into three major classes:

• Microbial pesticides consist of a microorganism (e.g., a bacterium, fungus, virus, or protozoan) as the active ingredient. Microbial pesticides can control many different kinds of pests, although each separate active ingredient is relatively specific for its target pest[s]. For example, there are fungi that control certain weeds, and other fungi that kill specific insects.

The most widely used microbial pesticides are subspecies and strains of Bacillus thuringiensis, or Bt. Each strain of this bacterium produces a different mix of proteins, and specifically kills one or a few related species of insect larvae. While some Bt's control moth larvae found on plants, other Bt's are specific for larvae of flies and mosquitoes. The target insect species are determined by whether the particular Bt produces a protein that can bind to a larval gut receptor, thereby causing the insect larvae to starve.

• Plant-Incorporated-Protectants (PIPs) are pesticidal substances that plants produce from genetic material that has been added to the plant. For example, scientists can take the gene for the Bt pesticidal protein, and introduce the gene into the plant's own genetic material. Then the plant, instead of the Bt bacterium, manufactures the substance that destroys the pest. The protein and its genetic material, but not the plant itself, are regulated by EPA.

• Biochemical pesticides are naturally occurring substances that control pests by non-toxic mechanisms. Conventional pesticides, by contrast, are, in general, synthetic materials that directly kill or inactivate the pest. Biochemical pesticides include substances, such as insect sex pheromones, that interfere with mating, as well as various scented plant extracts that attract insect pests to traps. Because it is sometimes difficult to determine whether a substance meets the criteria for classification as a biochemical pesticide, EPA has established a special committee to make such decisions.

Classified by type of pest

Pesticides that are related to the type of pests are:

Type	Action
Algicides	Control algae in lakes, canals, swimming pools, water tanks, and other sites
Antifouling agents	Kill or repel organisms that attach to underwater surfaces, such as boat bottoms
Antimicrobials	Kill microorganisms (such as bacteria and viruses)
Attractants	Attract pests (for example, to lure an insect or rodent to a trap). (However, food is not considered a pesticide when used as an attractant.)
Biopesticides	Biopesticides are certain types of pesticides derived from such natural materials as animals, plants, bacteria, and certain minerals
Biocides	Kill microorganisms
Disinfectants and sanitizers	Kill or inactivate disease-producing microorganisms on inanimate objects
Fungicides	Kill fungi (including blights, mildews, molds, and rusts)
Fumigants	Produce gas or vapor intended to destroy pests in buildings or soil
Herbicides	Kill weeds and other plants that grow where they are not wanted
Insecticides	Kill insects and other arthropods
Miticides	Kill mites that feed on plants and animals
Microbial pesticides	Microorganisms that kill, inhibit, or out compete pests, including insects or other microorganisms
Molluscicides	Kill snails and slugs
Nematicides	Kill nematodes (microscopic, worm-like organisms that feed on plant roots)
Ovicides	Kill eggs of insects and mites
Pheromones	Biochemicals used to disrupt the mating behavior of insects
Repellents	Repel pests, including insects (such as mosquitoes) and birds
Rodenticides	Control mice and other rodents

Further types of pesticides

The term pesticide also include these substances:

Defoliants : Cause leaves or other foliage to drop from a plant, usually to facilitate harvest.
Desiccants : Promote drying of living tissues, such as unwanted plant tops.
Insect growth regulators : Disrupt the molting, maturity from pupal stage to adult, or other life processes of insects.
Plant growth regulators : Substances (excluding fertilizers or other plant nutrients) that alter the expected growth, flowering, or reproduction rate of plants.

Uses

Pesticides are used to control organisms that are considered to be harmful.^[16] For example, they are used to kill mosquitoes that can transmit potentially deadly diseases like West Nile virus, yellow fever, and malaria. They can also kill bees, wasps or ants that can cause allergic reactions. Insecticides can protect animals from illnesses that can be caused by parasites such as fleas.^[16] Pesticides can prevent sickness in humans that could be caused by moldy food or diseased produce. Herbicides can be used to clear roadside weeds, trees and brush. They can also kill invasive weeds that may cause environmental damage. Herbicides are commonly applied in ponds and lakes to control algae and plants such as water grasses that can interfere with activities like swimming and fishing and cause the water to look or smell unpleasant.^[17] Uncontrolled pests such as termites and mould can damage structures such as houses.^[16] Pesticides are used in grocery stores and food storage facilities to manage rodents and insects that infest food such as grain. Each use of a pesticide carries some associated risk. Proper pesticide use decreases these associated risks to a level deemed acceptable by pesticide regulatory agencies such as the United States Environmental Protection Agency (EPA) and the Pest Management Regulatory Agency (PMRA) of Canada.

Pesticides can save farmers' money by preventing crop losses to insects and other pests; in the U.S., farmers get an estimated fourfold return on money they spend on pesticides.^[18] One study found that not using pesticides reduced crop yields by about 10%.^[19] Another study, conducted in 1999, found that a ban on pesticides in the United States may result in a rise of food prices, loss of jobs, and an increase in world hunger.^[20]

DDT, sprayed on the walls of houses, is an organochloride that has been used to fight malaria since the 1950s. Recent policy statements by the World Health Organization have given stronger support to this approach.^[21] Dr. Arata Kochi, WHO's malaria chief, said, "One of the best tools we have against malaria is indoor residual house spraying. Of the dozen insecticides WHO has approved as safe for house spraying, the most effective is DDT."^[21] However a later October 2007 study linked breast cancer from exposure to DDT prior to puberty.^[22] Poisoning may also occur due to use of DDT and other chlorinated hydrocarbons by entering the human food chain when animal tissues are affected. Symptoms include nervous excitement, tremors, convulsions, or death. Scientists estimate that DDT and other chemicals in the organophosphate class of pesticides have saved 7 million human lives since 1945 by preventing the transmission of diseases such as malaria, bubonic plague, sleeping sickness, and typhus.^[23] However, DDT use is not always effective, as resistance to DDT was identified in Africa as early as 1955, and by 1972 nineteen species of mosquito worldwide were resistant to DDT.^[24] A study for the World Health Organization in 2000 from Vietnam established that non-DDT malaria controls were significantly more effective than DDT use.^[25] The ecological effect of DDT on organisms is an example of bioaccumulation.

Quantity and variety

In 2006 and 2007, the world used approximately 5.2 billion pounds of pesticides, with herbicides constituting the biggest part of the world pesticide use at 40%, followed by insecticides (17%) and fungicides (10%). In 2006 and 2007 the U.S. used approximately 1.1 billion pounds of pesticides, accounting for 22% of the world total, including 857 million pounds of conventional pesticides, which are used in the agricultural sector (80% of conventional pesticide use) as well as the industrial, commercial, governmental and home & garden sectors.Pesticides are also found in majority of U.S. households with 78 million out of the 105.5 million households indicating that they use some form of pesticide.^[26] As of 2007, there were more than 1,055 active ingredients registered as pesticides,^[27] which yield over 20,000 pesticide products that are marketed in the United States.^[28]

The US used some 2.2 pounds per hactare of arable land compared with 10.3 in China, 3.0 in the UK, .2 in Cameroun, 13.1 in Japan and 5.6 in Italy. Insecticide use in the US has declined by more than half since 1980, (.6%/yr) mostly due to the near phase-out of organophosphates. In corn fields, the decline was even steeper, due to the switchover to transgenic Bt corn.^[29]

For the global market of crop protection products, market analysts forecast revenues of over 52 billion US$ in 2019.^[30]

Costs

On the cost side of pesticide use there can be costs to the environment, costs to human health,^[31] as well as costs of the development and research of new pesticides.

Health effects

Pesticides may cause acute and delayed health effects in workers who are exposed.^[32] Pesticide exposure can cause a variety of adverse health effects, ranging from simple irritation of the skin and eyes to more severe effects such as affecting the nervous system, mimicking hormones causing reproductive problems, and also causing cancer.^[33] A 2007 systematic review found that "most studies on non-Hodgkin lymphoma and leukemia showed positive associations with pesticide exposure" and thus concluded that cosmetic use of pesticides should be decreased.^[34] Strong evidence also exists for other negative outcomes from pesticide exposure including neurological, birth defects, fetal death,^[35] and neurodevelopmental disorder.^[36]

The American Medical Association recommends limiting exposure to pesticides and using safer alternatives:^[7] "Particular uncertainty exists regarding the long-term effects of low-dose pesticide exposures."

Even consuming organic food, these chemicals can have a negative health impact. Though the U.S. Environmental Protection Agency (EPA) limits the amount of each pesticide that may be present on a food item, there exists no limit to the number of different chemicals that can be used. This leads to a possibly even more dangerous effect known as a "chemical cocktail". The chemicals may form one of many dangerous interactions and have an unmeasured synergistic effect.^[37]

The World Health Organization and the UN Environment Programme estimate that each year, 3 million workers in agriculture in the developing world experience severe poisoning from pesticides, about 18,000 of whom die.^[23] According to one study, as many as 25 million workers in developing countries may suffer mild pesticide poisoning yearly.^[38]

One study found pesticide self-poisoning the method of choice in one third of suicides worldwide, and recommended, among other things, more restrictions on the types of pesticides that are most harmful to humans.^[39]

A 2007 study by the California Department of Public Health found that women in the first eight weeks of pregnancy who live near farm fields sprayed with the organochlorine pesticides dicofol and endosulfan are several times more likely to give birth to children with autism.^[40]

Environmental effect

Pesticide use raises a number of environmental concerns. Over 98% of sprayed insecticides and 95% of herbicides reach a destination other than their target species, including non-target species, air, water and soil.^[23] Pesticide drift occurs when pesticides suspended in the air as particles are carried by wind to other areas, potentially contaminating them. Pesticides are one of the causes of water pollution, and some pesticides are persistent organic pollutants and contribute to soil contamination.

In addition, pesticide use reduces biodiversity, reduces nitrogen fixation,^[41] contributes to pollinator decline,^{[42][43][44][45]} destroys habitat (especially for birds),^[46] and threatens endangered species.^[23]
Pests can develop a resistance to the pesticide (pesticide resistance), necessitating a new pesticide. Alternatively a greater dose of the pesticide can be used to counteract the resistance, although this will cause a worsening of the ambient pollution problem.

Since chlorinated hydrocarbon pesticides dissolve in fats and are not excreted, organisms tend to retain them almost indefinitely. Biological magnification is the process whereby these chlorinated hydrocarbons (pesticides) are more concentrated at each level of the food chain. Among marine animals, pesticide concentrations are higher in carnivorous fishes, and even more so in the fish-eating birds and mammals at the top of the ecological pyramid.^[47] Global distillation is the process whereby pesticides are transported from warmer to colder regions of the Earth, in particular the Poles and mountain tops. Pesticides that evaporate into the atmosphere at relatively high temperature can be carried considerable distances (thousands of kilometers) by the wind to an area of lower temperature, where they condense and are carried back to the ground in rain or snow.^[48]

In order to reduce negative impacts, it is desirable that pesticides be degradable or at least quickly deactivated in the environment. Such loss of activity or toxicity of pesticides is due to both innate chemical properties of the compounds and environmental processes or conditions.^[49] For example, the presence of halogens within a chemical structure often slows down degradation in an aerobic environment.^[50] Adsorption to soil may retard pesticide movement, but also may reduce bioavailability to microbial degraders.^[51]

Economics

Harm	Annual US Cost
Public Health	$1.1 billion
Pesticide Resistance in Pest	$1.5 billion
Crop Losses Caused by Pesticides	$1.4 billion
Bird Losses due to Pesticides	$2.2 billion
Groundwater Contamination	$2.0 billion
Other Costs	$1.4 billion
Total Costs	$9.6 billion

Human health and environmental cost from pesticides in the United States is estimated at $9.6 billion:^[52]

Additional costs include the registration process and the cost of purchasing pesticides. The registration process can take several years to complete (there are 70 different types of field test) and can cost $50–70 million for a single pesticide.^[52] Annually the United States spends $10 billion on pesticides.^[52]

Benefits

There are two levels of benefits for pesticide use, primary and secondary. Primary benefits are direct gains from the use of pesticides and secondary benefits are effects that are more long-term.^[53]

Primary benefits

1. Controlling pests and plant disease vectors

• Improved crop/livestock yields
• Improved crop/livestock quality
• Invasive species controlled

2. Controlling human/livestock disease vectors and nuisance organisms

• Human lives saved and suffering reduced
• Animal lives saved and suffering reduced
• Diseases contained geographically

3. Controlling organisms that harm other human activities and structures

• Drivers view unobstructed
• Tree/brush/leaf hazards prevented
• Wooden structures protected ^[53]

Monetary

Every dollar ($1) that is spent on pesticides for crops yields four dollars ($4) in crops saved.^[54] This means based that, on the amount of money spent per year on pesticides, $10 billion, there is an additional $40 billion savings in crop that would be lost due to damage by insects and weeds. In general, farmers benefit from having an increase in crop yield and from being able to grow a variety of crops throughout the year. Consumers of agricultural products also benefit from being able to afford the vast quantities of produce available year-round.^[53] The general public also benefits from the use of pesticides for the control of insect-borne diseases and illnesses, such as malaria.^[53] The use of pesticides creates a large job market, which provides jobs for all of the people working within the industry.

Alternatives

Alternatives to pesticides are available and include methods of cultivation, use of biological pest controls (such as pheromones and microbial pesticides), genetic engineering, and methods of interfering with insect breeding.^[23] Application of composted yard waste has also been used as a way of controlling pests.^[55] These methods are becoming increasingly popular and often are safer than traditional chemical pesticides. In addition, EPA is registering reduced-risk conventional pesticides in increasing numbers.

Cultivation practices include polyculture (growing multiple types of plants), crop rotation, planting crops in areas where the pests that damage them do not live, timing planting according to when pests will be least problematic, and use of trap crops that attract pests away from the real crop.^[23] In the U.S., farmers have had success controlling insects by spraying with hot water at a cost that is about the same as pesticide spraying.^[23]

Release of other organisms that fight the pest is another example of an alternative to pesticide use. These organisms can include natural predators or parasites of the pests.^[23] Biological pesticides based on entomopathogenic fungi, bacteria and viruses cause disease in the pest species can also be used.^[23]

Interfering with insects' reproduction can be accomplished by sterilizing males of the target species and releasing them, so that they mate with females but do not produce offspring.^[23] This technique was first used on the screwworm fly in 1958 and has since been used with the medfly, the tsetse fly,^[56] and the gypsy moth.^[57] However, this can be a costly, time consuming approach that only works on some types of insects.^[23]

Another alternative to pesticides is the thermal treatment of soil through steam. Soil steaming kills pest and increases soil health.^{[citation needed]}

In India, traditional pest control methods include using Panchakavya, the "mixture of five products." The method has recently experienced a resurgence in popularity due in part to use by the organic farming community.^{[citation needed]}

Push pull strategy

The term "push-pull" was established in 1987 as an approach for integrated pest management (IPM). This strategy uses a mixture of behavior-modifying stimuli to manipulate the distribution and abundance of insects. "Push" means the insects are repelled or deterred away from whatever resource that is being protected. "Pull" means that certain stimuli (semiochemical stimuli, pheromones, food additives, visual stimuli, genetically altered plants, etc.) are used to attract pests to trap crops where they will be killed ^[58] There are numerous different components involved in order to implement a Push-Pull Strategy in IPM.

Many case studies testing the effectiveness of the push-pull approach have been done across the world. The most successful push-pull strategy was developed in Africa for subsistence farming. Another successful case study was performed on the control of Helicoverpa in cotton crops in Australia. In Europe, the Middle East, and the United States, push-pull strategies were successfully used in the controlling of Sitona lineatus in bean fields.^[58]

Some advantages of using the push-pull method are less use of chemical or biological materials and better protection against insect habituation to this control method. Some disadvantages of the push-pull strategy is that if there is a lack of appropriate knowledge of behavioral and chemical ecology of the host-pest interactions then this method becomes unreliable. Furthermore, because the push-pull method is not a very popular method of IPM operational and registration costs are higher.^[59]

Effectiveness

Some evidence shows that alternatives to pesticides can be equally effective as the use of chemicals. For example, Sweden has halved its use of pesticides with hardly any reduction in crops.^[23] In Indonesia, farmers have reduced pesticide use on rice fields by 65% and experienced a 15% crop increase.^[23] A study of Maize fields in northern Florida found that the application of composted yard waste with high carbon to nitrogen ratio to agricultural fields was highly effective at reducing the population of plant-parasitic nematodes and increasing crop yield, with yield increases ranging from 10% to 212%; the observed effects were long-term, often not appearing until the third season of the study.^[55]

However, pesticide resistance is increasing. In the 1940s, U.S. farmers lost only 7% of their crops to pests. Since the 1980s, loss has increased to 13%, even though more pesticides are being used. Between 500 and 1,000 insect and weed species have developed pesticide resistance since 1945.^[60]

Regulation

International

In most countries, pesticides must be approved for sale and use by a government agency.^[61]

In Europe, recent EU legislation has been approved banning the use of highly toxic pesticides including those that are carcinogenic, mutagenic or toxic to reproduction, those that are endocrine-disrupting, and those that are persistent, bioaccumulative and toxic (PBT) or very persistent and very bioaccumulative (vPvB). ^{[citation needed]} Measures were approved to improve the general safety of pesticides across all EU member states.^[62]

Though pesticide regulations differ from country to country, pesticides, and products on which they were used are traded across international borders. To deal with inconsistencies in regulations among countries, delegates to a conference of the United Nations Food and Agriculture Organization adopted an International Code of Conduct on the Distribution and Use of Pesticides in 1985 to create voluntary standards of pesticide regulation for different countries.^[61] The Code was updated in 1998 and 2002.^[63] The FAO claims that the code has raised awareness about pesticide hazards and decreased the number of countries without restrictions on pesticide use.^[5]

Three other efforts to improve regulation of international pesticide trade are the United Nations London Guidelines for the Exchange of Information on Chemicals in International Trade and the United Nations Codex Alimentarius Commission ^{[citation needed]}. The former seeks to implement procedures for ensuring that prior informed consent exists between countries buying and selling pesticides, while the latter seeks to create uniform standards for maximum levels of pesticide residues among participating countries.^[64] Both initiatives operate on a voluntary basis.^[64]

Pesticide safety education and pesticide applicator regulation are designed to protect the public from pesticide misuse, but do not eliminate all misuse. Reducing the use of pesticides and choosing less toxic pesticides may reduce risks placed on society and the environment from pesticide use.^[17] Integrated pest management, the use of multiple approaches to control pests, is becoming widespread and has been used with success in countries such as Indonesia, China, Bangladesh, the U.S., Australia, and Mexico.^[23] IPM attempts to recognize the more widespread impacts of an action on an ecosystem, so that natural balances are not upset.^[65] New pesticides are being developed, including biological and botanical derivatives and alternatives that are thought to reduce health and environmental risks. In addition, applicators are being encouraged to consider alternative controls and adopt methods that reduce the use of chemical pesticides.

Pesticides can be created that are targeted to a specific pest's lifecycle, which can be environmentally more friendly.^[66] For example, potato cyst nematodes emerge from their protective cysts in response to a chemical excreted by potatoes; they feed on the potatoes and damage the crop.^[66] A similar chemical can be applied to fields early, before the potatoes are planted, causing the nematodes to emerge early and starve in the absence of potatoes.^[66]

United States

In the United States, the Environmental Protection Agency (EPA) is responsible for regulating pesticides under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and the Food Quality Protection Act (FQPA).^[67] Studies must be conducted to establish the conditions in which the material is safe to use and the effectiveness against the intended pest(s).^[68] The EPA regulates pesticides to ensure that these products do not pose adverse effects to humans or the environment. Pesticides produced before November 1984 continue to be reassessed in order to meet the current scientific and regulatory standards. All registered pesticides are reviewed every 15 years to ensure they meet the proper standards.^[67] During the registration process, a label is created. The label contains directions for proper use of the material in addition to safety restrictions. Based on acute toxicity, pesticides are assigned to a Toxicity Class.

Some pesticides are considered too hazardous for sale to the general public and are designated restricted use pesticides. Only certified applicators, who have passed an exam, may purchase or supervise the application of restricted use pesticides.^[61] Records of sales and use are required to be maintained and may be audited by government agencies charged with the enforcement of pesticide regulations.^[69][70] These records must be made available to employees and state or territorial environmental regulatory agencies.^[71][72]

The EPA regulates pesticides under two main acts, both of which amended by the Food Quality Protection Act of 1996. In addition to the EPA, the United States Department of Agriculture (USDA) and the United States Food and Drug Administration (FDA) set standards for the level of pesticide residue that is allowed on or in crops.^[73] The EPA looks at what the potential human health and environmental effects might be associated with the use of the pesticide.^[74]

In addition, the U.S. EPA uses the National Research Council's four-step process for human health risk assessment: (1) Hazard Identification, (2) Dose-Response Assessment, (3) Exposure Assessment, and (4) Risk Characterization.^[75]

Recently Kaua'i County (Hawai'i) passed Bill No. 2491 to add an article to Chapter 22 of the county's code relating to pesticides and GMOs. The bill strengthens protections of local communities in Kaua'i where many large pesticide companies test their products.^[76]

History

Since before 2000 BC, humans have utilized pesticides to protect their crops. The first known pesticide was elemental sulfur dusting used in ancient Sumer about 4,500 years ago in ancient Mesopotamia. The Rig Veda, which is about 4,000 years old, mentions the use of poisonous plants for pest control.^[77] By the 15th century, toxic chemicals such as arsenic, mercury, and lead were being applied to crops to kill pests. In the 17th century, nicotine sulfate was extracted from tobacco leaves for use as an insecticide. The 19th century saw the introduction of two more natural pesticides, pyrethrum, which is derived from chrysanthemums, and rotenone, which is derived from the roots of tropical vegetables.^[78] Until the 1950s, arsenic-based pesticides were dominant.^[79] Paul Müller discovered that DDT was a very effective insecticide. Organochlorines such as DDT were dominant, but they were replaced in the U.S. by organophosphates and carbamates by 1975. Since then, pyrethrin compounds have become the dominant insecticide.^[79] Herbicides became common in the 1960s, led by "triazine and other nitrogen-based compounds, carboxylic acids such as 2,4-dichlorophenoxyacetic acid, and glyphosate".^[79]

The first legislation providing federal authority for regulating pesticides was enacted in 1910;^[80] however, decades later during the 1940s manufacturers began to produce large amounts of synthetic pesticides and their use became widespread.^[65] Some sources consider the 1940s and 1950s to have been the start of the "pesticide era."^[81] Although the U.S. Environmental Protection Agency was established in 1970 and amendments to the pesticide law in 1972,^[82] pesticide use has increased 50-fold since 1950 and 2.3 million tonnes (2.5 million short tons) of industrial pesticides are now used each year.^[78] Seventy-five percent of all pesticides in the world are used in developed countries, but use in developing countries is increasing.^[23] In 2001 the EPA stopped reporting yearly pesticide use statistics. A study of USA pesticide use trends through 1997 was published in 2003 by the National Science Foundation's Center for Integrated Pest Management.^[79][83]

In the 1960s, it was discovered that DDT was preventing many fish-eating birds from reproducing, which was a serious threat to biodiversity. Rachel Carson wrote the best-selling book Silent Spring about biological magnification. The agricultural use of DDT is now banned under the Stockholm Convention on Persistent Organic Pollutants, but it is still used in some developing nations to prevent malaria and other tropical diseases by spraying on interior walls to kill or repel mosquitoes.^[84]

See also

• Index of pesticide articles
• Pesticide residue
• Pest control

References

Further reading

Books

• Greene, Stanley A.; Pohanish, Richard P. (editors) (2005). Sittig's Handbook of Pesticides and Agricultural Chemicals. SciTech Publishing, Inc. ISBN 0-8155-1516-2. 
• Tomlin, Clive (editor) (2006). "The Pesticide Manual", 14th edition, 1350 pages. British Crop Protection Council (BCPC). ISBN 1-901396-14-2. 
• Hamilton, Denis; Crossley, Stephen (editors) (2004). Pesticide residues in food and drinking water. J. Wiley. ISBN 0-471-48991-3. 
• Hond, Frank et al. (2003). Pesticides: problems, improvements, alternatives. Blackwell Science. ISBN 0-632-05659-2. 
• Kegley, Susan E.; Wise, Laura J. (1998). Pesticides in fruits and vegetables. University Science Books. ISBN 0-935702-46-6. 
• Levine, Marvin J. (2007). Pesticides: A Toxic Time Bomb in our Midst. Praeger Publishers. ISBN 978-0-275-99127-2. 
• Ware, George W.; Whitacre, David M. (2004). Pesticide Book. Meister Publishing Co. ISBN 1-892829-11-8. 
• Watson, David H. (editor) (2004). Pesticide, veterinary and other residues in food. Woodhead Publishing. ISBN 1-85573-734-5. 

Journal articles

• Walter A. Alarcon, et al. (July 2005). "Acute Illnesses Associated With Pesticide Exposure at Schools". Journal of the American Medical Association 294 (4): 455–465. doi:10.1001/jama.294.4.455. PMID 16046652. 
• World Health Organization Persistent Organic Pollutants: Impact on Child Health

News

• Janofsky, M (August 4, 2006). "E.P.A. recommends limits on thousands of uses of pesticides". New York Times. Retrieved 2006-08-24. 
• Janofsky, M (2006-08-02). "Unions say E.P.A. bends to political pressure". New York Times. Retrieved 2007-10-10. 
• Kaiser, J (June 2005). "Endocrine disrupters trigger fertility problems in multiple generations". Science 308 (5727): 1391–1392. doi:10.1126/science.308.5727.1391a. PMID 15933166. 
• Kaiser, J (May 2005). "House would foil human pesticide studies". Science 308 (5726): 1234. doi:10.1126/science.308.5726.1234b. PMID 15919959. 
• Webster, P (Dec 2004). "Study finds heavy contamination across vast Russian Arctic". Science 306 (5703): 1875. doi:10.1126/science.306.5703.1875a. PMID 15591171. 
• Stokstad, E (Nov 2004). "EPA criticized for study of child pesticide exposure". Science 306 (5698): 961. doi:10.1126/science.306.5698.961. PMID 15528421. 
• Helmuth, L (Nov 2000). "Pesticide causes Parkinson's in rats". Science 290 (5494): 1068. doi:10.1126/science.290.5494.1068a. PMID 11184997. 
• Adam, D (Nov 2000). "Pesticide use linked to Parkinson's disease". Nature 408 (6809): 125. doi:10.1038/35041740. PMID 11089940. 

External links

Wikimedia Commons has media related to Pesticides.

• National Pesticide Information Center (NPIC) Information about pesticide-related topics.
• Pesticide laws guidance on NetRegs.gov.uk
• Pesticide Modes of action (International Pesticide Application Research Centre)
• Beyond Pesticides, founded in 1981 as the National Coalition Against the Misuse of Pesticides - Source of information on pesticide hazards, least-toxic practices and products, and on pesticide issues. Website has Daily News Blog relating to pesticides.
• Compendium of Pesticide Common Names: Classified Lists of Pesticides Lists of pesticide names by type.
• Pesticide Action Network. PAN Pesticides Database. Compilation of multiple regulatory databases into a web-accessible form.
• Pesticide pathfinder Information about pesticide use in the workplace and links to U.S regulatory information.
• USDA Pesticide Data Program, tracking residue levels in food
• Snell Scientifics Pesticide Development Lab General Pesticide Development Information

Pesticide regulatory authorities

• College voor toelating bestrijdingsmiddelen en biociden. Regulatory authority in the Netherlands - information available in English
• UK Pesticides Safety Directorate
• European Commission pesticide information
• Lake Ontario Waterkeeper (May 21, 2008) -- Pesticide legislation suggests industry lobby is still alive and well
• United States Environmental Protection Agency Office of Pesticides Program
• [http://iaspub.epa.gov/apex/pesticides/f?p=CHEMICALSEARCH:1:2397994685836501::NO:1:: US EPA Pesticide Chemical Search]

Human health

• NIH encyclopedia pages with emergency treatment of Insecticide exposure
• Durango Software - Provides risk assessment tools for pesticide use
• Environmental Working Group (July 14, 2005), The Pollution in Newborns.
• Hazard Communications for Agricultural Workers (October 2007)
• National Agricultural Workers Survey
• Pesticides and Health -- Greenpeace China
• David Suzuki Foundation: Protecting Your Health from Pesticides
• Estimation of human intake of pesticides from all potential pathways by L Tran, R Glass, P Ritchie, A Sleeuwenhoek, L MacCalman, J Cherrie. Institute of Occupational Medicine Research Report TM/08/01
• Field evaluation of protective clothing against non-agricultural pesticides by A Soutar and others. Institute of Occupational Medicine Research Report TM/00/04
• A comparison of different methods for assessment of dermal exposure to nonagricultural pesticides in three sectors by SN Tannahill and others. Institute of Occupational Medicine Research Report TM/96/07

v t e Pesticides Pesticide types Acaricide Bactericide Biocide Bioherbicide Biopesticide Fungicide Herbicide Insecticide Molluscicide Nematicide Piscicide Rodenticide Related topics Health effects Environmental effects Fumigation Agricultural spray adjuvant Biological pest control Gene silencing Green pest management Integrated pest management Maximum residue limit Non-pesticide management Persistent organic pollutant Pest control Application Drift Formulation Misuse Paradox of the pesticides Poisoning Research Residue Resistance Bee toxicity Restricted use Pesticide Action Network Toxicity Class The Pesticide Question By country Canada European Union New Zealand United States Integrated Pest Management Index of pesticide articles Pesticide categories

v t e Horticulture and gardening Gardening History Design computer-aided Garden tool Green wall Arboretum Allotment Butterfly Community Forest French intensive Guerilla Garden Landscape Native Parterre Raised bed Square foot Sustainable Xeriscaping Types of gardens Back Biblical Botanical Butterfly zoo Byzantine Color Container Cottage Cactus Chinese Dutch English Fernery Floating Flower French formal landscape Renaissance Front Greek Greenhouse Hanging Islamic Italian Japanese Kitchen Knot Korean Market Mary Mughal Orangery Orchard Persian Bagh Charbagh Paradise Philosophical Pleasure Roman Spanish Rain Rose Roof Sacred Sensory Shade Therapeutic Trial Tropical Victory Vineyard Walled Water Wildlife Winter Zen Zoological Horticulture Agriculture stock-free sustainable urban Arboriculture Botany Companion planting Crop Flora Floriculture Fruticulture Genetically modified tree Hydroculture Indigenous Intercropping Landscape architecture Oenology Olericulture Plant breeding propagation Postharvest physiology Tropical Urban agriculture horticulture forestry reforestation Viticulture Organic Biodynamic agriculture List of organic gardening and farming topics Vegan organic gardening Plant protection Fungicide Herbicide Index of pesticide articles List of fungicides Pesticide Plant disease forecasting Weed control Agriculture and Agronomy portal Gardening portal Commons

v t e Food safety Adulterants / food contaminants 3-MCPD Aldicarb Cyanide Formaldehyde Lead poisoning Melamine Mercury in fish Sudan I Flavorings Monosodium glutamate (MSG) Salt Sugar Microorganisms Botulism Campylobacter jejuni Clostridium perfringens Escherichia coli O104:H4 Escherichia coli O157:H7 Hepatitis A Hepatitis E Listeria Norovirus Rotavirus Salmonella Pesticides Chlorpyrifos DDT Lindane Malathion Methamidophos Preservatives Benzoic acid Ethylenediaminetetraacetic acid (EDTA) Sodium benzoate Sugar substitutes Acesulfame potassium Aspartame High fructose corn syrup health effects public relations Saccharin Sodium cyclamate Sorbitol Sucralose Toxins / poisons Aflatoxin Arsenic contamination of groundwater Benzene in soft drinks Bisphenol A Mycotoxins Shellfish poisoning Food contamination incidents 1858 Bradford sweets poisoning 1989 Chilean grape scare 1993 Jack in the Box E. coli outbreak 2005 Indonesia food scare 2006 North American E. coli O157:H7 outbreaks 2007 Vietnam food scare 2008 Canada listeriosis outbreak 2008 Chinese milk scandal 2008 Irish pork crisis 2008 United States salmonellosis outbreak 2011 Germany E. coli O104:H4 outbreak 2011 Taiwan food scandal 2011 United States listeriosis outbreak Food safety incidents in China Foodborne illness outbreaks death toll United States ICA meat repackaging controversy Minamata disease Starlink corn recall Toxic oil syndrome 2013 meat adulteration scandal 2013 aflatoxin contamination 2013 Taiwan food scandal Regulatory / watchdog Acceptable daily intake E number Food labeling regulations Food libel laws International Food Safety Network Quality Assurance International Food processing 4-Hydroxynonenal Acid-hydrolyzed vegetable protein Acrylamide Creutzfeldt–Jakob disease Food additives Food irradiation Heterocyclic amines Modified starch Nitrosamines Polycyclic aromatic hydrocarbon Shortening Trans fat Related topics Curing (food preservation) Food marketing Food politics Food preservation Food quality Genetically modified food Taboo food and drink

v t e Neurotoxins Animal Batrachotoxin Bestoxin Birtoxin Bungarotoxin Charybdotoxin Conotoxin Saxitoxin Tetrodotoxin Vanillotoxin Huwentoxin Bacterial Botulinum toxin Tetanospasmin Plant Penitrem A Picrotoxin Bicuculline Pesticides Rotenone Nerve agents Cyclosarin EA-3148 Novichok agent Sarin Soman Tabun VE VG VM VR VX Neurotoxic drugs 1,4-BD 5,7-DHT 6-OHDA αET αMT Dizocilpine (MK-801) DSP-4 Ethanol GBL GHB Ibotenic acid Ketamine Methamphetamine MBDB MDA MDEA MDMA (Ecstasy) MPP+ MPTP Norsalsolinol PBA PCA PIA Phencyclidine (PCP) Denaturants Methanol

v t e Pollution Air pollution Acid rain Air quality index Atmospheric dispersion modeling Chlorofluorocarbon Indoor air quality Global dimming Global distillation Global warming Ozone depletion Atmospheric particulate matter Smog Water pollution Environmental impact of pharmaceuticals and personal care products Environmental impact of shipping Environmental monitoring Eutrophication Freshwater environmental quality parameters Hypoxia Marine debris Marine pollution Ocean acidification Oil spill Surface runoff Thermal pollution Urban runoff Waste water Water quality Water stagnation Waterborne diseases Soil contamination Bioremediation Phytoremediation Electrical resistance heating Herbicide Pesticide Soil Guideline Values (SGVs) Radioactive contamination Actinides in the environment Environmental radioactivity Fission product Nuclear fallout Plutonium in the environment Radiation poisoning Radium in the environment Uranium in the environment Other types of pollution Urban heat island Land degradation Light pollution Nanopollution Noise pollution Radio spectrum pollution Visual pollution Inter-government treaties Basel Convention CLRTAP Kyoto Protocol MARPOL Convention Montreal Protocol OSPAR Stockholm Convention Major organizations Basel Action Network DEFRA Environment Agency (England and Wales) Scottish Environment Protection Agency (Scotland) U.S. EPA EEA Greenpeace